Suppressor cell induction in vitro. I. Kinetics of induction of antigen-specific suppressor cells.
The induction of antigen-specific suppressor cells in vitro, using high concentrations (100 mug/ml) of keyhole limpet hemocyanin (KLH) in Marbrook flasks is described. Spleen and cortisone-resistant thymocytes were the richest source of suppressor cell precursors, compared to lymph node cells, perip...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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1976
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| _version_ | 1826279741088333824 |
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| author | Kontiainen, S Feldmann, M |
| author_facet | Kontiainen, S Feldmann, M |
| author_sort | Kontiainen, S |
| collection | OXFORD |
| description | The induction of antigen-specific suppressor cells in vitro, using high concentrations (100 mug/ml) of keyhole limpet hemocyanin (KLH) in Marbrook flasks is described. Spleen and cortisone-resistant thymocytes were the richest source of suppressor cell precursors, compared to lymph node cells, peripheral blood lymphocytes or thoracic duct lymphocytes. Suppressor cells induced with KLH only suppressed KLH-reactive helper cells, and not B cells or helper cells of other specificity. The suppressor cells were T cells, as judged by their sensitivity to anti-Thy-1.2, heterologous anti-T, but not anti-B antisera. |
| first_indexed | 2024-03-07T00:03:18Z |
| format | Journal article |
| id | oxford-uuid:76b669ee-b62d-4945-bd69-30b40cb34f80 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:03:18Z |
| publishDate | 1976 |
| record_format | dspace |
| spelling | oxford-uuid:76b669ee-b62d-4945-bd69-30b40cb34f802022-03-26T20:18:01ZSuppressor cell induction in vitro. I. Kinetics of induction of antigen-specific suppressor cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:76b669ee-b62d-4945-bd69-30b40cb34f80EnglishSymplectic Elements at Oxford1976Kontiainen, SFeldmann, MThe induction of antigen-specific suppressor cells in vitro, using high concentrations (100 mug/ml) of keyhole limpet hemocyanin (KLH) in Marbrook flasks is described. Spleen and cortisone-resistant thymocytes were the richest source of suppressor cell precursors, compared to lymph node cells, peripheral blood lymphocytes or thoracic duct lymphocytes. Suppressor cells induced with KLH only suppressed KLH-reactive helper cells, and not B cells or helper cells of other specificity. The suppressor cells were T cells, as judged by their sensitivity to anti-Thy-1.2, heterologous anti-T, but not anti-B antisera. |
| spellingShingle | Kontiainen, S Feldmann, M Suppressor cell induction in vitro. I. Kinetics of induction of antigen-specific suppressor cells. |
| title | Suppressor cell induction in vitro. I. Kinetics of induction of antigen-specific suppressor cells. |
| title_full | Suppressor cell induction in vitro. I. Kinetics of induction of antigen-specific suppressor cells. |
| title_fullStr | Suppressor cell induction in vitro. I. Kinetics of induction of antigen-specific suppressor cells. |
| title_full_unstemmed | Suppressor cell induction in vitro. I. Kinetics of induction of antigen-specific suppressor cells. |
| title_short | Suppressor cell induction in vitro. I. Kinetics of induction of antigen-specific suppressor cells. |
| title_sort | suppressor cell induction in vitro i kinetics of induction of antigen specific suppressor cells |
| work_keys_str_mv | AT kontiainens suppressorcellinductioninvitroikineticsofinductionofantigenspecificsuppressorcells AT feldmannm suppressorcellinductioninvitroikineticsofinductionofantigenspecificsuppressorcells |