HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies

HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies

Broadly neutralizing antibody (bnAb) induction is a high priority for effective HIV-1 vaccination. VRC01-class bnAbs that target the CD4 binding site (CD4bs) of trimeric HIV-1 envelope (Env) glycoprotein spikes are particularly attractive to elicit because of their extraordinary breadth and potency...

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Bibliographic Details
Main Authors: Labranche, CC, McGuire, AT, Gray, MD, Behrens, S, Zhou, T, Sattentau, QJ, Peacock, J, Eaton, A, Greene, K, Gao, H, Tang, H, Perez, LG, Saunders, KO, Mascola, JR, Haynes, BF, Stamatatos, L, Montefiori, DC
Format: Journal article
Language:English
Published: Public Library of Science 2018

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