On the role of receptor downregulation and costimulation in shaping the T cell response

On the role of receptor downregulation and costimulation in shaping the T cell response

<p>T cells are critical decision-makers in the immune system and their activation determines whether a cell or molecule constitutes a threat to the body and needs to be eliminated or whether it should be ignored and tolerated by the immune system. Many molecules that play a role in T cell a...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Kruger, P
Awduron Eraill:	Dushek, O
Fformat:	Traethawd Ymchwil
Cyhoeddwyd:	2018
Pynciau:	Systems Biology Immunology

Eitemau Tebyg

A quantitative analysis of the contribution of costimulation to T cell activation by the T cell receptor and chimeric antigen receptors
gan: Patel, AB
Cyhoeddwyd: (2023)

CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation
gan: Kathryn E. Beckermann, et al.
Cyhoeddwyd: (2020-08-01)

Phenotypic modelling of the polyfunctional T cell response
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Cyhoeddwyd: (2018)

Linked sensitization by memory CD4+ T cells prevents costimulation blockade–induced transplantation tolerance
gan: Michael S. Andrade, et al.
Cyhoeddwyd: (2022-06-01)

Evaluating the glycolytic potential of mouse costimulated effector CD8+ T cells ex vivo
gan: Federica Agliano, et al.
Cyhoeddwyd: (2022-06-01)

Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation
gan: Yale Liu, et al.
Cyhoeddwyd: (2020-10-01)

The downregulation of IL-18R defines bona fide kidney-resident CD8+ T cells
gan: Wei Liao, et al.
Cyhoeddwyd: (2021-01-01)

Dissecting the impact of chimeric antigen receptor expression levels on T cell behaviour and response
gan: Ramos, AS
Cyhoeddwyd: (2022)

Role of Toll-like receptors in costimulating cytotoxic T cell responses.
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First Responders Shape a Prompt and Sharp NF-κB-Mediated Transcriptional Response to TNF-α
gan: Samuel Zambrano, et al.
Cyhoeddwyd: (2020-09-01)

Rituximab and obinutuzumab differentially hijack the B cell receptor and NOTCH1 signaling pathways
gan: Jennifer Edelmann, et al.
Cyhoeddwyd: (2021-02-01)

Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation
gan: Sara Zumerle, et al.
Cyhoeddwyd: (2017-11-01)

Barcoding intracellular reverse transcription enables high-throughput phenotype-coupled T cell receptor analyses
gan: Sahana Jayaraman, et al.
Cyhoeddwyd: (2023-10-01)

Cellular and Molecular Changes of Brain Metastases-Associated Myeloid Cells during Disease Progression and Therapeutic Response
gan: Michael Schulz, et al.
Cyhoeddwyd: (2020-06-01)

Murine cytomegalovirus downregulates ERAAP and induces an unconventional T cell response to self
gan: Kristina M. Geiger, et al.
Cyhoeddwyd: (2023-04-01)

The Cytokine Receptor IL-7Rα Impairs IL-2 Receptor Signaling and Constrains the In Vitro Differentiation of Foxp3+ Treg Cells
gan: Adam T. Waickman, et al.
Cyhoeddwyd: (2020-08-01)

LncRNA TYMSOS facilitates breast cancer metastasis and immune escape through downregulating ULBP3
gan: Ke-Jing Zhang, et al.
Cyhoeddwyd: (2023-09-01)

The role of protease-activated receptor 1 signaling in CD8 T cell effector functions
gan: Hui Chen, et al.
Cyhoeddwyd: (2021-11-01)

Direct activation of toll-like receptor 4 signaling in group 2 innate lymphoid cells contributes to inflammatory responses of allergic diseases
gan: Li She, et al.
Cyhoeddwyd: (2024-11-01)

The IL-27 receptor regulates TIGIT on memory CD4+ T cells during sepsis
gan: Kristen N. Morrow, et al.
Cyhoeddwyd: (2021-02-01)

Shaping Polyclonal Responses via Antigen-Mediated Antibody Interference
gan: Le Yan, et al.
Cyhoeddwyd: (2020-10-01)

A Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy
gan: Samira Imran, et al.
Cyhoeddwyd: (2020-06-01)

Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells
gan: Christophe M. Capelle, et al.
Cyhoeddwyd: (2021-04-01)

Differential Roles of the Calcium Ion Channel TRPV4 in Host Responses to Mycobacterium tuberculosis Early and Late in Infection
gan: Sumanta Kumar Naik, et al.
Cyhoeddwyd: (2020-06-01)

BCG therapy downregulates HLA-I on malignant cells to subvert antitumor immune responses in bladder cancer
gan: Mathieu Rouanne, et al.
Cyhoeddwyd: (2022-06-01)

Assessment of Fcγ receptor-dependent binding of influenza hemagglutinin vaccine-induced antibodies in a non-human primate model
gan: Yuji Masuta, et al.
Cyhoeddwyd: (2022-10-01)

The role of type I interferons in regulating intestinal inflammation
gan: Kole, A
Cyhoeddwyd: (2013)

Integrating Systems Biology and an Ex Vivo Human Tumor Model Elucidates PD-1 Blockade Response Dynamics
gan: Munisha Smalley, et al.
Cyhoeddwyd: (2020-06-01)

Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury
gan: Michelangelo Bauwelz Gonzatti, et al.
Cyhoeddwyd: (2023-10-01)

Distinct T cell receptor repertoire diversity of clinically defined high-grade serous ovarian cancer treatment subgroups
gan: Sanghoon Lee, et al.
Cyhoeddwyd: (2021-02-01)

Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging
gan: Maarten P. Bebelman, et al.
Cyhoeddwyd: (2023-08-01)

Small transcriptional differences among cell clones lead to distinct NF-κB dynamics
gan: Cise Kizilirmak, et al.
Cyhoeddwyd: (2023-12-01)

Investigating primary and secondary B cell responses in cattle after immunisation with existing and novel vaccines
gan: Grant, C
Cyhoeddwyd: (2013)

Immune Literacy: Reading, Writing, and Editing Adaptive Immunity
gan: Lucia Csepregi, et al.
Cyhoeddwyd: (2020-09-01)

Mass Cytometry Phenotyping of Human Granulocytes Reveals Novel Basophil Functional Heterogeneity
gan: Nora Vivanco Gonzalez, et al.
Cyhoeddwyd: (2020-11-01)

Lack of canonical thyroid hormone receptor α signaling changes regulatory T cell phenotype in female mice
gan: Christina Wenzek, et al.
Cyhoeddwyd: (2024-08-01)

BCL11B is positioned upstream of PLZF and RORγt to control thymic development of mucosal-associated invariant T cells and MAIT17 program
gan: Theodore T. Drashansky, et al.
Cyhoeddwyd: (2021-04-01)

Nicotinamide breaks effector CD8 T cell responses by targeting mTOR signaling
gan: Federica Agliano, et al.
Cyhoeddwyd: (2022-03-01)

Phosphorylation of extracellular signal-regulated kinase as a biomarker for cannabinoid receptor 2 activation
gan: Jingru Wang, et al.
Cyhoeddwyd: (2018-11-01)

Development of chimeric antigen receptor (CAR)-T cells targeting A56 viral protein implanted by oncolytic virus
gan: Euna Cho, et al.
Cyhoeddwyd: (2024-03-01)