On the role of receptor downregulation and costimulation in shaping the T cell response

On the role of receptor downregulation and costimulation in shaping the T cell response

<p>T cells are critical decision-makers in the immune system and their activation determines whether a cell or molecule constitutes a threat to the body and needs to be eliminated or whether it should be ignored and tolerated by the immune system. Many molecules that play a role in T cell a...

Fuld beskrivelse

Bibliografiske detaljer
Hovedforfatter:	Kruger, P
Andre forfattere:	Dushek, O
Format:	Thesis
Udgivet:	2018
Fag:	Systems Biology Immunology

Lignende værker

A quantitative analysis of the contribution of costimulation to T cell activation by the T cell receptor and chimeric antigen receptors
af: Patel, AB
Udgivet: (2023)

CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation
af: Kathryn E. Beckermann, et al.
Udgivet: (2020-08-01)

Phenotypic modelling of the polyfunctional T cell response
af: Trendel, N
Udgivet: (2018)

Linked sensitization by memory CD4+ T cells prevents costimulation blockade–induced transplantation tolerance
af: Michael S. Andrade, et al.
Udgivet: (2022-06-01)

Evaluating the glycolytic potential of mouse costimulated effector CD8+ T cells ex vivo
af: Federica Agliano, et al.
Udgivet: (2022-06-01)

Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation
af: Yale Liu, et al.
Udgivet: (2020-10-01)

The downregulation of IL-18R defines bona fide kidney-resident CD8+ T cells
af: Wei Liao, et al.
Udgivet: (2021-01-01)

Dissecting the impact of chimeric antigen receptor expression levels on T cell behaviour and response
af: Ramos, AS
Udgivet: (2022)

Role of Toll-like receptors in costimulating cytotoxic T cell responses.
af: Schwarz, K, et al.
Udgivet: (2003)

First Responders Shape a Prompt and Sharp NF-κB-Mediated Transcriptional Response to TNF-α
af: Samuel Zambrano, et al.
Udgivet: (2020-09-01)

Rituximab and obinutuzumab differentially hijack the B cell receptor and NOTCH1 signaling pathways
af: Jennifer Edelmann, et al.
Udgivet: (2021-02-01)

Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation
af: Sara Zumerle, et al.
Udgivet: (2017-11-01)

Barcoding intracellular reverse transcription enables high-throughput phenotype-coupled T cell receptor analyses
af: Sahana Jayaraman, et al.
Udgivet: (2023-10-01)

Cellular and Molecular Changes of Brain Metastases-Associated Myeloid Cells during Disease Progression and Therapeutic Response
af: Michael Schulz, et al.
Udgivet: (2020-06-01)

Murine cytomegalovirus downregulates ERAAP and induces an unconventional T cell response to self
af: Kristina M. Geiger, et al.
Udgivet: (2023-04-01)

The Cytokine Receptor IL-7Rα Impairs IL-2 Receptor Signaling and Constrains the In Vitro Differentiation of Foxp3+ Treg Cells
af: Adam T. Waickman, et al.
Udgivet: (2020-08-01)

LncRNA TYMSOS facilitates breast cancer metastasis and immune escape through downregulating ULBP3
af: Ke-Jing Zhang, et al.
Udgivet: (2023-09-01)

The role of protease-activated receptor 1 signaling in CD8 T cell effector functions
af: Hui Chen, et al.
Udgivet: (2021-11-01)

Direct activation of toll-like receptor 4 signaling in group 2 innate lymphoid cells contributes to inflammatory responses of allergic diseases
af: Li She, et al.
Udgivet: (2024-11-01)

The IL-27 receptor regulates TIGIT on memory CD4+ T cells during sepsis
af: Kristen N. Morrow, et al.
Udgivet: (2021-02-01)

Shaping Polyclonal Responses via Antigen-Mediated Antibody Interference
af: Le Yan, et al.
Udgivet: (2020-10-01)

A Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy
af: Samira Imran, et al.
Udgivet: (2020-06-01)

Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells
af: Christophe M. Capelle, et al.
Udgivet: (2021-04-01)

Differential Roles of the Calcium Ion Channel TRPV4 in Host Responses to Mycobacterium tuberculosis Early and Late in Infection
af: Sumanta Kumar Naik, et al.
Udgivet: (2020-06-01)

BCG therapy downregulates HLA-I on malignant cells to subvert antitumor immune responses in bladder cancer
af: Mathieu Rouanne, et al.
Udgivet: (2022-06-01)

Assessment of Fcγ receptor-dependent binding of influenza hemagglutinin vaccine-induced antibodies in a non-human primate model
af: Yuji Masuta, et al.
Udgivet: (2022-10-01)

The role of type I interferons in regulating intestinal inflammation
af: Kole, A
Udgivet: (2013)

Integrating Systems Biology and an Ex Vivo Human Tumor Model Elucidates PD-1 Blockade Response Dynamics
af: Munisha Smalley, et al.
Udgivet: (2020-06-01)

Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury
af: Michelangelo Bauwelz Gonzatti, et al.
Udgivet: (2023-10-01)

Distinct T cell receptor repertoire diversity of clinically defined high-grade serous ovarian cancer treatment subgroups
af: Sanghoon Lee, et al.
Udgivet: (2021-02-01)

Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging
af: Maarten P. Bebelman, et al.
Udgivet: (2023-08-01)

Small transcriptional differences among cell clones lead to distinct NF-κB dynamics
af: Cise Kizilirmak, et al.
Udgivet: (2023-12-01)

Investigating primary and secondary B cell responses in cattle after immunisation with existing and novel vaccines
af: Grant, C
Udgivet: (2013)

Immune Literacy: Reading, Writing, and Editing Adaptive Immunity
af: Lucia Csepregi, et al.
Udgivet: (2020-09-01)

Mass Cytometry Phenotyping of Human Granulocytes Reveals Novel Basophil Functional Heterogeneity
af: Nora Vivanco Gonzalez, et al.
Udgivet: (2020-11-01)

Lack of canonical thyroid hormone receptor α signaling changes regulatory T cell phenotype in female mice
af: Christina Wenzek, et al.
Udgivet: (2024-08-01)

BCL11B is positioned upstream of PLZF and RORγt to control thymic development of mucosal-associated invariant T cells and MAIT17 program
af: Theodore T. Drashansky, et al.
Udgivet: (2021-04-01)

Nicotinamide breaks effector CD8 T cell responses by targeting mTOR signaling
af: Federica Agliano, et al.
Udgivet: (2022-03-01)

Phosphorylation of extracellular signal-regulated kinase as a biomarker for cannabinoid receptor 2 activation
af: Jingru Wang, et al.
Udgivet: (2018-11-01)

Development of chimeric antigen receptor (CAR)-T cells targeting A56 viral protein implanted by oncolytic virus
af: Euna Cho, et al.
Udgivet: (2024-03-01)