Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway.

Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway.

(3R,5R)-Clavulanic acid (CA) is a clinically important inhibitor of Class A beta-lactamases. Sequence comparisons suggest that orf14 of the clavulanic acid biosynthesis gene cluster encodes for an acetyl transferase (CBG). Crystallographic studies reveal CBG to be a member of the emerging structural...

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Bibliographic Details
Main Authors: Iqbal, A, Arunlanantham, H, Brown, T, Chowdhury, R, Clifton, I, Kershaw, N, Hewitson, K, McDonough, M, Schofield, C
Format: Journal article
Language:English
Published: 2010

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