Nitrogen-containing bisphosphonates of varying antiresorptive potency have been co-crystallized in farnesyl diphosphate synthase and modelled to understand the key structural features involved in enzyme inhibition.

Geahča maid

• Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
  Dahkki: Ebetino, F, et al.
  Almmustuhtton: (2006)
• Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonates
  Dahkki: Evdokimov, A, et al.
  Almmustuhtton: (2006)
• Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
  Dahkki: Ebetino, F, et al.
  Almmustuhtton: (2006)
• Refining structure activity relationships among nitrogen containing bisphosphonates: Dissociation of mineral binding affinity and inhibitory potency on farnesyl diphosphate synthase.
  Dahkki: Xia, Z, et al.
  Almmustuhtton: (2006)
• Molecular interactions of nitrogen-containing bisphosphonates within farnesyl diphosphate synthase
  Dahkki: Ebetino, F, et al.
  Almmustuhtton: (2005)