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Nitrogen-containing bisphosphonates of varying antiresorptive potency have been co-crystallized in farnesyl diphosphate synthase and modelled to understand the key structural features involved in enzyme inhibition.

Nitrogen-containing bisphosphonates of varying antiresorptive potency have been co-crystallized in farnesyl diphosphate synthase and modelled to understand the key structural features involved in enzyme inhibition.

Bibliografiska uppgifter
Huvudupphovsmän: Ebetino, F, Barnett, B, Roze, C, Kashemirov, B, McKenna, C, Evdokimov, A, Pokross, M, Dunford, J, Opermann, U, Kavanagh, K, Rogers, M, Russell, R
Materialtyp: Conference item
Publicerad: 2006
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Liknande verk

  • Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
    av: Ebetino, F, et al.
    Publicerad: (2006)
  • Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonates
    av: Evdokimov, A, et al.
    Publicerad: (2006)
  • Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
    av: Ebetino, F, et al.
    Publicerad: (2006)
  • Refining structure activity relationships among nitrogen containing bisphosphonates: Dissociation of mineral binding affinity and inhibitory potency on farnesyl diphosphate synthase.
    av: Xia, Z, et al.
    Publicerad: (2006)
  • Molecular interactions of nitrogen-containing bisphosphonates within farnesyl diphosphate synthase
    av: Ebetino, F, et al.
    Publicerad: (2005)

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