Structural and mechanistic studies on γ-butyrobetaine hydroxylase.

Structural and mechanistic studies on γ-butyrobetaine hydroxylase.

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The final step in carnitine biosynthesis is catalyzed by γ-butyrobetaine (γBB) hydroxylase (BBOX), an iron/2-oxoglutarate (2OG) dependent oxygenase. BBOX is inhibited by trimethylhydrazine-propionate (THP), a clinically used compound. We report structural and mechanistic studies on BBOX and its reac...

書目詳細資料
Main Authors:	Leung, I, Krojer, T, Kochan, G, Henry, L, von Delft, F, Claridge, T, Oppermann, U, McDonough, M, Schofield, C
格式:	Journal article
語言:	English
出版:	2010

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