Structural and mechanistic studies on γ-butyrobetaine hydroxylase.

Structural and mechanistic studies on γ-butyrobetaine hydroxylase.

عرض إصدارات أخرى (1)

The final step in carnitine biosynthesis is catalyzed by γ-butyrobetaine (γBB) hydroxylase (BBOX), an iron/2-oxoglutarate (2OG) dependent oxygenase. BBOX is inhibited by trimethylhydrazine-propionate (THP), a clinically used compound. We report structural and mechanistic studies on BBOX and its reac...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Leung, I, Krojer, T, Kochan, G, Henry, L, von Delft, F, Claridge, T, Oppermann, U, McDonough, M, Schofield, C
التنسيق:	Journal article
اللغة:	English
منشور في:	2010

مواد مشابهة

Structural and mechanistic studies on γ-butyrobetaine hydroxylase.
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منشور في: (2010)

Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase.
حسب: Rydzik, A, وآخرون
منشور في: (2014)

Development and application of a fluoride-detection-based fluorescence assay for γ-butyrobetaine hydroxylase.
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منشور في: (2012)

γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement.
حسب: Henry, L, وآخرون
منشور في: (2012)

γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement
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منشور في: (2012)

Development and application of ligand-based NMR screening assays for γ-butyrobetaine hydroxylase
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Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase.
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منشور في: (2014)

¹⁹F NMR studies on 𝛾-Butyrobetaine Hydroxylase provide mechanistic insights and suggest a dual inhibition mode
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منشور في: (2010)

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منشور في: (2007)

Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase.
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منشور في: (2011)

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Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.
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Substrate selectivity of prolyl hydroxylases
حسب: McDonough, M
منشور في: (2018)

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منشور في: (2023-11-01)

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
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Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids
حسب: Rydzik, A, وآخرون
منشور في: (2014)

Oxygenase-catalyzed desymmetrization of N,N-dialkyl-piperidine-4-carboxylic acids.
حسب: Rydzik, A, وآخرون
منشور في: (2014)

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern
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منشور في: (2019-10-01)

Structural basis of prolyl hydroxylase domain inhibition by Molidustat
حسب: Figg, WD, وآخرون
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The Association of Circulating L-Carnitine, γ-Butyrobetaine and Trimethylamine N-Oxide Levels with Gastric Cancer
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Inhibition of hypoxia inducible factor (HIF) hydroxylases
حسب: Conejo-Garcia, A, وآخرون
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Structural and mechanistic studies on prolyl hydroxylases
حسب: Chowdhury, R
منشور في: (2008)

DETERMINATION OF MELDONIUM, γ-BUTYROBETAINE, AND CARNITINE IN BLOOD PLASMA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS-SELECTIVE DETECTION
حسب: P. N. Sorokoumov, وآخرون
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Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
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حسب: Brewitz, L, وآخرون
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Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2
حسب: Figg, WD, وآخرون
منشور في: (2023)

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases
حسب: Horita, S, وآخرون
منشور في: (2015)

Inhibition of the oxygen-sensing asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor: a potential hypoxia response modulating strategy
حسب: Wu, Y, وآخرون
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Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis.
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Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
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A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation
حسب: Li, Z, وآخرون
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Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
حسب: Lennart Brewitz, وآخرون
منشور في: (2020-12-01)