Structural and mechanistic studies on γ-butyrobetaine hydroxylase.

Structural and mechanistic studies on γ-butyrobetaine hydroxylase.

Show other versions (1)

The final step in carnitine biosynthesis is catalyzed by γ-butyrobetaine (γBB) hydroxylase (BBOX), an iron/2-oxoglutarate (2OG) dependent oxygenase. BBOX is inhibited by trimethylhydrazine-propionate (THP), a clinically used compound. We report structural and mechanistic studies on BBOX and its reac...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Leung, I, Krojer, T, Kochan, G, Henry, L, von Delft, F, Claridge, T, Oppermann, U, McDonough, M, Schofield, C
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2010

Eitemau Tebyg

Structural and mechanistic studies on γ-butyrobetaine hydroxylase.
gan: Leung, I, et al.
Cyhoeddwyd: (2010)

Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase.
gan: Rydzik, A, et al.
Cyhoeddwyd: (2014)

Development and application of a fluoride-detection-based fluorescence assay for γ-butyrobetaine hydroxylase.
gan: Rydzik, A, et al.
Cyhoeddwyd: (2012)

γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement.
gan: Henry, L, et al.
Cyhoeddwyd: (2012)

γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement
gan: Henry, L, et al.
Cyhoeddwyd: (2012)

Development and application of ligand-based NMR screening assays for γ-butyrobetaine hydroxylase
gan: Claridge, T, et al.
Cyhoeddwyd: (2016)

Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase.
gan: Rydzik, A, et al.
Cyhoeddwyd: (2014)

¹⁹F NMR studies on 𝛾-Butyrobetaine Hydroxylase provide mechanistic insights and suggest a dual inhibition mode
gan: Leśniak, RK, et al.
Cyhoeddwyd: (2019)

Modulating carnitine levels by targeting its biosynthesis - selective inhibition of gamma-butyrobetaine hydroxylase
gan: Rydzik, A, et al.
Cyhoeddwyd: (2014)

Mechanistic and inhibition studies on gamma-butyrobetaine hydroxylase
gan: Rydzik, AM
Cyhoeddwyd: (2014)

Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6.
gan: Mantri, M, et al.
Cyhoeddwyd: (2010)

Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6.
gan: Mantri, M, et al.
Cyhoeddwyd: (2010)

Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH).
gan: Schofield, C, et al.
Cyhoeddwyd: (2007)

Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase.
gan: Zhang, Z, et al.
Cyhoeddwyd: (2011)

A simplified method for the measurement of gamma-butyrobetaine hydroxylase activity.
gan: S Englard, et al.
Cyhoeddwyd: (1978-11-01)

Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.
gan: McDonough, M, et al.
Cyhoeddwyd: (2005)

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern
gan: Pfeffer, I, et al.
Cyhoeddwyd: (2019)

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.
gan: Hewitson, K, et al.
Cyhoeddwyd: (2007)

Substrate selectivity of prolyl hydroxylases
gan: McDonough, M
Cyhoeddwyd: (2018)

A review on the role of gamma-butyrobetaine hydroxylase 1 antisense RNA 1 in the carcinogenesis and tumor progression
gan: Juan Hu, et al.
Cyhoeddwyd: (2023-11-01)

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
gan: Lancaster, D, et al.
Cyhoeddwyd: (2004)

Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids
gan: Rydzik, A, et al.
Cyhoeddwyd: (2014)

Oxygenase-catalyzed desymmetrization of N,N-dialkyl-piperidine-4-carboxylic acids.
gan: Rydzik, A, et al.
Cyhoeddwyd: (2014)

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern
gan: Inga Pfeffer, et al.
Cyhoeddwyd: (2019-10-01)

Structural basis of prolyl hydroxylase domain inhibition by Molidustat
gan: Figg, WD, et al.
Cyhoeddwyd: (2021)

The Association of Circulating L-Carnitine, γ-Butyrobetaine and Trimethylamine N-Oxide Levels with Gastric Cancer
gan: Ilmārs Stonāns, et al.
Cyhoeddwyd: (2023-04-01)

Inhibition of hypoxia inducible factor (HIF) hydroxylases
gan: Conejo-Garcia, A, et al.
Cyhoeddwyd: (2005)

Structural and mechanistic studies on prolyl hydroxylases
gan: Chowdhury, R
Cyhoeddwyd: (2008)

DETERMINATION OF MELDONIUM, γ-BUTYROBETAINE, AND CARNITINE IN BLOOD PLASMA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS-SELECTIVE DETECTION
gan: P. N. Sorokoumov, et al.
Cyhoeddwyd: (2019-01-01)

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
gan: Chowdhury, R, et al.
Cyhoeddwyd: (2009)

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
gan: Brewitz, L, et al.
Cyhoeddwyd: (2020)

Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2
gan: Figg, WD, et al.
Cyhoeddwyd: (2023)

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases
gan: Horita, S, et al.
Cyhoeddwyd: (2015)

Inhibition of the oxygen-sensing asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor: a potential hypoxia response modulating strategy
gan: Wu, Y, et al.
Cyhoeddwyd: (2021)

Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis.
gan: Sleeman, M, et al.
Cyhoeddwyd: (2005)

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
gan: Lennart Brewitz, et al.
Cyhoeddwyd: (2020-05-01)

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
gan: Holt-Martyn, J, et al.
Cyhoeddwyd: (2019)

A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation
gan: Li, Z, et al.
Cyhoeddwyd: (2020)

Mechanistic and structural study of human aspartate/asparagine-beta-hydroxylase
gan: Brasnett, A
Cyhoeddwyd: (2023)

Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
gan: Lennart Brewitz, et al.
Cyhoeddwyd: (2020-12-01)