Structural and mechanistic studies on γ-butyrobetaine hydroxylase.

Structural and mechanistic studies on γ-butyrobetaine hydroxylase.

他のバージョン（1件）を表示する

The final step in carnitine biosynthesis is catalyzed by γ-butyrobetaine (γBB) hydroxylase (BBOX), an iron/2-oxoglutarate (2OG) dependent oxygenase. BBOX is inhibited by trimethylhydrazine-propionate (THP), a clinically used compound. We report structural and mechanistic studies on BBOX and its reac...

書誌詳細
主要な著者:	Leung, I, Krojer, T, Kochan, G, Henry, L, von Delft, F, Claridge, T, Oppermann, U, McDonough, M, Schofield, C
フォーマット:	Journal article
言語:	English
出版事項:	2010

類似資料

Structural and mechanistic studies on γ-butyrobetaine hydroxylase.
著者:: Leung, I, 等
出版事項: (2010)

Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase.
著者:: Rydzik, A, 等
出版事項: (2014)

Development and application of a fluoride-detection-based fluorescence assay for γ-butyrobetaine hydroxylase.
著者:: Rydzik, A, 等
出版事項: (2012)

γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement.
著者:: Henry, L, 等
出版事項: (2012)

γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement
著者:: Henry, L, 等
出版事項: (2012)

Development and application of ligand-based NMR screening assays for γ-butyrobetaine hydroxylase
著者:: Claridge, T, 等
出版事項: (2016)

Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase.
著者:: Rydzik, A, 等
出版事項: (2014)

¹⁹F NMR studies on 𝛾-Butyrobetaine Hydroxylase provide mechanistic insights and suggest a dual inhibition mode
著者:: Leśniak, RK, 等
出版事項: (2019)

Modulating carnitine levels by targeting its biosynthesis - selective inhibition of gamma-butyrobetaine hydroxylase
著者:: Rydzik, A, 等
出版事項: (2014)

Mechanistic and inhibition studies on gamma-butyrobetaine hydroxylase
著者:: Rydzik, AM
出版事項: (2014)

Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6.
著者:: Mantri, M, 等
出版事項: (2010)

Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6.
著者:: Mantri, M, 等
出版事項: (2010)

Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH).
著者:: Schofield, C, 等
出版事項: (2007)

Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase.
著者:: Zhang, Z, 等
出版事項: (2011)

A simplified method for the measurement of gamma-butyrobetaine hydroxylase activity.
著者:: S Englard, 等
出版事項: (1978-11-01)

Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.
著者:: McDonough, M, 等
出版事項: (2005)

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern
著者:: Pfeffer, I, 等
出版事項: (2019)

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.
著者:: Hewitson, K, 等
出版事項: (2007)

Substrate selectivity of prolyl hydroxylases
著者:: McDonough, M
出版事項: (2018)

A review on the role of gamma-butyrobetaine hydroxylase 1 antisense RNA 1 in the carcinogenesis and tumor progression
著者:: Juan Hu, 等
出版事項: (2023-11-01)

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
著者:: Lancaster, D, 等
出版事項: (2004)

Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids
著者:: Rydzik, A, 等
出版事項: (2014)

Oxygenase-catalyzed desymmetrization of N,N-dialkyl-piperidine-4-carboxylic acids.
著者:: Rydzik, A, 等
出版事項: (2014)

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern
著者:: Inga Pfeffer, 等
出版事項: (2019-10-01)

Structural basis of prolyl hydroxylase domain inhibition by Molidustat
著者:: Figg, WD, 等
出版事項: (2021)

The Association of Circulating L-Carnitine, γ-Butyrobetaine and Trimethylamine N-Oxide Levels with Gastric Cancer
著者:: Ilmārs Stonāns, 等
出版事項: (2023-04-01)

Inhibition of hypoxia inducible factor (HIF) hydroxylases
著者:: Conejo-Garcia, A, 等
出版事項: (2005)

Structural and mechanistic studies on prolyl hydroxylases
著者:: Chowdhury, R
出版事項: (2008)

DETERMINATION OF MELDONIUM, γ-BUTYROBETAINE, AND CARNITINE IN BLOOD PLASMA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS-SELECTIVE DETECTION
著者:: P. N. Sorokoumov, 等
出版事項: (2019-01-01)

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
著者:: Chowdhury, R, 等
出版事項: (2009)

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
著者:: Brewitz, L, 等
出版事項: (2020)

Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2
著者:: Figg, WD, 等
出版事項: (2023)

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases
著者:: Horita, S, 等
出版事項: (2015)

Inhibition of the oxygen-sensing asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor: a potential hypoxia response modulating strategy
著者:: Wu, Y, 等
出版事項: (2021)

Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis.
著者:: Sleeman, M, 等
出版事項: (2005)

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
著者:: Lennart Brewitz, 等
出版事項: (2020-05-01)

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
著者:: Holt-Martyn, J, 等
出版事項: (2019)

A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation
著者:: Li, Z, 等
出版事項: (2020)

Mechanistic and structural study of human aspartate/asparagine-beta-hydroxylase
著者:: Brasnett, A
出版事項: (2023)

Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
著者:: Lennart Brewitz, 等
出版事項: (2020-12-01)