Neuroendocrine and temperature effects of nefazodone in healthy volunteers.
The effects of a novel antidepressant, nefazodone (50 mg, 100 mg, and 200 mg orally) on neuroendocrine function and temperature were assessed using a single-blind, crossover design in eight healthy male volunteers. Nefazodone significantly increased plasma levels of prolactin (PRL) and raised oral t...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1993
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| _version_ | 1797076461074513920 |
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| author | Walsh, A Hockney, R Campling, G Cowen, P |
| author_facet | Walsh, A Hockney, R Campling, G Cowen, P |
| author_sort | Walsh, A |
| collection | OXFORD |
| description | The effects of a novel antidepressant, nefazodone (50 mg, 100 mg, and 200 mg orally) on neuroendocrine function and temperature were assessed using a single-blind, crossover design in eight healthy male volunteers. Nefazodone significantly increased plasma levels of prolactin (PRL) and raised oral temperature. There was also a trend towards an increase in plasma cortisol. These results are consistent with an acute facilitatory effect of some aspects of 5-HT neurotransmission, perhaps mediated through nefazodone's metabolism to its major metabolite, m-chlorophenylpiperazine (mCPP). |
| first_indexed | 2024-03-07T00:04:07Z |
| format | Journal article |
| id | oxford-uuid:76f4e336-18c5-4da0-a357-0aa83e83fcab |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:04:07Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:76f4e336-18c5-4da0-a357-0aa83e83fcab2022-03-26T20:19:54ZNeuroendocrine and temperature effects of nefazodone in healthy volunteers.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:76f4e336-18c5-4da0-a357-0aa83e83fcabEnglishSymplectic Elements at Oxford1993Walsh, AHockney, RCampling, GCowen, PThe effects of a novel antidepressant, nefazodone (50 mg, 100 mg, and 200 mg orally) on neuroendocrine function and temperature were assessed using a single-blind, crossover design in eight healthy male volunteers. Nefazodone significantly increased plasma levels of prolactin (PRL) and raised oral temperature. There was also a trend towards an increase in plasma cortisol. These results are consistent with an acute facilitatory effect of some aspects of 5-HT neurotransmission, perhaps mediated through nefazodone's metabolism to its major metabolite, m-chlorophenylpiperazine (mCPP). |
| spellingShingle | Walsh, A Hockney, R Campling, G Cowen, P Neuroendocrine and temperature effects of nefazodone in healthy volunteers. |
| title | Neuroendocrine and temperature effects of nefazodone in healthy volunteers. |
| title_full | Neuroendocrine and temperature effects of nefazodone in healthy volunteers. |
| title_fullStr | Neuroendocrine and temperature effects of nefazodone in healthy volunteers. |
| title_full_unstemmed | Neuroendocrine and temperature effects of nefazodone in healthy volunteers. |
| title_short | Neuroendocrine and temperature effects of nefazodone in healthy volunteers. |
| title_sort | neuroendocrine and temperature effects of nefazodone in healthy volunteers |
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