Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target

Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target

The three human SNM1 metallo-β-lactamase fold nucleases (SNM1A–C) play key roles in DNA damage repair and in maintaining telomere integrity. Genetic studies indicate that they are attractive targets for cancer treatment and to potentiate chemo- and radiation-therapy. A high-throughput screen for SNM...

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Príomhchruthaitheoirí: Bielinski, M, Henderson, LR, Yosaatmadja, Y, Swift, LP, Baddock, HT, Bowen, MJ, Brem, J, Jones, PS, McElroy, SP, Morrison, A, Speake, M, van Boeckel, S, van Doornmalen, E, van Groningen, J, van den Hurk, H, Gileadi, O, Newman, JA, McHugh, PJ, Schofield, CJ
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: Royal Society of Chemistry 2024

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