Growth, collapse, and stalling in a mechanical model for neurite motility
Neurites, the long cellular protrusions that form the routes of the neuronal network are capable to actively extend during early morphogenesis or to regenerate after trauma. To perform this task, they rely on their cytoskeleton for mechanical support. In this paper, we present a threecomponent activ...
| Egile Nagusiak: | , , |
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| Formatua: | Journal article |
| Argitaratua: |
American Physical Society
2016
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| _version_ | 1826279833642991616 |
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| author | Recho, P Jerusalem, A Goriely, A |
| author_facet | Recho, P Jerusalem, A Goriely, A |
| author_sort | Recho, P |
| collection | OXFORD |
| description | Neurites, the long cellular protrusions that form the routes of the neuronal network are capable to actively extend during early morphogenesis or to regenerate after trauma. To perform this task, they rely on their cytoskeleton for mechanical support. In this paper, we present a threecomponent active gel model that describes neurites in the three robust mechanical states observed experimentally: collapsed, static, and motile. These states arise from an interplay between the physical forces driven by growth of the microtubule-rich inner core of the neurite and the actomyosin contractility of its surrounding cortical membrane. In particular, static states appear as a mechanical traction/compression balance of these two parallel structures. The model predicts how the response of a neurite to a towing force depends on the force magnitude and recovers the response of neurites to several drug treatments that modulate the cytoskeleton active and passive properties. |
| first_indexed | 2024-03-07T00:04:42Z |
| format | Journal article |
| id | oxford-uuid:77271a9c-9dd2-48cb-8f15-748ad763a212 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T00:04:42Z |
| publishDate | 2016 |
| publisher | American Physical Society |
| record_format | dspace |
| spelling | oxford-uuid:77271a9c-9dd2-48cb-8f15-748ad763a2122022-03-26T20:21:58ZGrowth, collapse, and stalling in a mechanical model for neurite motilityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:77271a9c-9dd2-48cb-8f15-748ad763a212Symplectic Elements at OxfordAmerican Physical Society2016Recho, PJerusalem, AGoriely, ANeurites, the long cellular protrusions that form the routes of the neuronal network are capable to actively extend during early morphogenesis or to regenerate after trauma. To perform this task, they rely on their cytoskeleton for mechanical support. In this paper, we present a threecomponent active gel model that describes neurites in the three robust mechanical states observed experimentally: collapsed, static, and motile. These states arise from an interplay between the physical forces driven by growth of the microtubule-rich inner core of the neurite and the actomyosin contractility of its surrounding cortical membrane. In particular, static states appear as a mechanical traction/compression balance of these two parallel structures. The model predicts how the response of a neurite to a towing force depends on the force magnitude and recovers the response of neurites to several drug treatments that modulate the cytoskeleton active and passive properties. |
| spellingShingle | Recho, P Jerusalem, A Goriely, A Growth, collapse, and stalling in a mechanical model for neurite motility |
| title | Growth, collapse, and stalling in a mechanical model for neurite motility |
| title_full | Growth, collapse, and stalling in a mechanical model for neurite motility |
| title_fullStr | Growth, collapse, and stalling in a mechanical model for neurite motility |
| title_full_unstemmed | Growth, collapse, and stalling in a mechanical model for neurite motility |
| title_short | Growth, collapse, and stalling in a mechanical model for neurite motility |
| title_sort | growth collapse and stalling in a mechanical model for neurite motility |
| work_keys_str_mv | AT rechop growthcollapseandstallinginamechanicalmodelforneuritemotility AT jerusalema growthcollapseandstallinginamechanicalmodelforneuritemotility AT gorielya growthcollapseandstallinginamechanicalmodelforneuritemotility |