Glucocorticoids inhibit osteoblast proliferation via transcriptional upregulation of MKP-1: A prime target for the development of novel osteo-anabolic agents

Eitemau Tebyg

• Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1
  gan: Horsch, K, et al.
  Cyhoeddwyd: (2004)
• Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1
  gan: Horsch, K, et al.
  Cyhoeddwyd: (2004)
• Vanadate protects osteoblasts in vitro and in vivo from glucocorticoid impairment of proliferation
  gan: Hulley, P, et al.
  Cyhoeddwyd: (2002)
• MKP-1 knockout does not prevent glucocorticoid-induced bone disease in mice.
  gan: Conradie, M, et al.
  Cyhoeddwyd: (2011)
• Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines.
  gan: Engelbrecht, Y, et al.
  Cyhoeddwyd: (2003)