Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria
The majority of routinely given vaccines require two or three immunisations for full protective efficacy. Single dose vaccination has long been considered a key solution to improving the global immunisation coverage. Recent infectious disease outbreaks have further highlighted the need for vaccines...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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Springer Nature
2017
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| _version_ | 1826279848005337088 |
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| author | Milicic, A Rollier, C Tang, C Longley, R Hill, A Reyes-Sandoval, A |
| author_facet | Milicic, A Rollier, C Tang, C Longley, R Hill, A Reyes-Sandoval, A |
| author_sort | Milicic, A |
| collection | OXFORD |
| description | The majority of routinely given vaccines require two or three immunisations for full protective efficacy. Single dose vaccination has long been considered a key solution to improving the global immunisation coverage. Recent infectious disease outbreaks have further highlighted the need for vaccines that can achieve full efficacy after a single administration. Viral vectors are a potent immunisation platform, benefiting from intrinsic immuno-stimulatory features while retaining excellent safety profile through the use of non-replicating viruses. We investigated the scope for enhancing the protective efficacy of a single dose adenovirus-vectored malaria vaccine in a mouse model of malaria by co-administering it with vaccine adjuvants. Out of 11 adjuvants, only two, Abisco(®)-100 and CoVaccineHT(TM), enhanced vaccine efficacy and sterile protection following malaria challenge. The CoVaccineHT(TM) adjuvanted vaccine induced significantly higher proportion of antigen specific central memory CD8(+) cells, and both adjuvants resulted in increased proportion of CD8(+) T cells expressing the CD107a degranulation marker in the absence of IFNγ, TNFα and IL2 production. Our results show that the efficacy of vaccines designed to induce protective T cell responses can be positively modulated with chemical adjuvants and open the possibility of achieving full protection with a single dose immunisation. |
| first_indexed | 2024-03-07T00:04:55Z |
| format | Journal article |
| id | oxford-uuid:773add9e-10aa-4d81-9f86-654e8c93569a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:04:55Z |
| publishDate | 2017 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:773add9e-10aa-4d81-9f86-654e8c93569a2022-03-26T20:22:26ZAdjuvanting a viral vectored vaccine against pre-erythrocytic malariaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:773add9e-10aa-4d81-9f86-654e8c93569aEnglishSymplectic Elements at OxfordSpringer Nature2017Milicic, ARollier, CTang, CLongley, RHill, AReyes-Sandoval, AThe majority of routinely given vaccines require two or three immunisations for full protective efficacy. Single dose vaccination has long been considered a key solution to improving the global immunisation coverage. Recent infectious disease outbreaks have further highlighted the need for vaccines that can achieve full efficacy after a single administration. Viral vectors are a potent immunisation platform, benefiting from intrinsic immuno-stimulatory features while retaining excellent safety profile through the use of non-replicating viruses. We investigated the scope for enhancing the protective efficacy of a single dose adenovirus-vectored malaria vaccine in a mouse model of malaria by co-administering it with vaccine adjuvants. Out of 11 adjuvants, only two, Abisco(®)-100 and CoVaccineHT(TM), enhanced vaccine efficacy and sterile protection following malaria challenge. The CoVaccineHT(TM) adjuvanted vaccine induced significantly higher proportion of antigen specific central memory CD8(+) cells, and both adjuvants resulted in increased proportion of CD8(+) T cells expressing the CD107a degranulation marker in the absence of IFNγ, TNFα and IL2 production. Our results show that the efficacy of vaccines designed to induce protective T cell responses can be positively modulated with chemical adjuvants and open the possibility of achieving full protection with a single dose immunisation. |
| spellingShingle | Milicic, A Rollier, C Tang, C Longley, R Hill, A Reyes-Sandoval, A Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria |
| title | Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria |
| title_full | Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria |
| title_fullStr | Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria |
| title_full_unstemmed | Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria |
| title_short | Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria |
| title_sort | adjuvanting a viral vectored vaccine against pre erythrocytic malaria |
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