Histological determinants of survival in completely resected T1-2N1M0 nonsmall cell cancer of the lung.
BACKGROUND: The histologic determinants of survival after surgical resection of stage II nonsmall cell lung cancer are poorly understood. We analyzed the prognostic significance of a number of histologic features after complete resection of T1-2N1M0 nonsmall cell cancer of the lung. METHODS: The ca...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2004
|
| _version_ | 1797076528880680960 |
|---|---|
| author | Khan, O Fitzgerald, J Field, M Soomro, I Beggs, F Morgan, W Duffy, J |
| author_facet | Khan, O Fitzgerald, J Field, M Soomro, I Beggs, F Morgan, W Duffy, J |
| author_sort | Khan, O |
| collection | OXFORD |
| description | BACKGROUND: The histologic determinants of survival after surgical resection of stage II nonsmall cell lung cancer are poorly understood. We analyzed the prognostic significance of a number of histologic features after complete resection of T1-2N1M0 nonsmall cell cancer of the lung. METHODS: The case notes and histology of all patients who underwent a potentially curative surgical resection for T1-2N1M0 nonsmall cell carcinoma of the lung between 1991 and 1997 were reviewed retrospectively. The following histologic factors were recorded: histologic type of tumor; number of nodes with metastatic deposits together with their nodal station; the presence of vascular invasion, visceral pleural involvement, and cellular necrosis; and grade of tumor. The results from 98 patients were analyzed. Univariate and multivariate analyses were performed to identify prognostic factors. RESULTS: Univariate analysis showed that only three factors had a statistically significant correlation with a poor prognosis: vascular invasion (p = 0.002), nonsquamous histology (p = 0.005), and visceral pleural involvement (p = 0.002). Multivariate analysis revealed that all three factors were significant independent adverse prognostic indicators. CONCLUSIONS: Visceral pleural involvement, nonsquamous histology, and vascular invasion are all significant adverse prognostic factors after surgical resection of T1-2N1M0 nonsmall cell cancer of the lung. These findings conflict with previously published reports, and we advocate a prospective, large-scale study in order to clarify the prognostic significance of histologic characteristics in stage II disease. |
| first_indexed | 2024-03-07T00:05:00Z |
| format | Journal article |
| id | oxford-uuid:77421720-de4b-448b-9b85-88c311a0eb5b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:05:00Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:77421720-de4b-448b-9b85-88c311a0eb5b2022-03-26T20:22:44ZHistological determinants of survival in completely resected T1-2N1M0 nonsmall cell cancer of the lung.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:77421720-de4b-448b-9b85-88c311a0eb5bEnglishSymplectic Elements at Oxford2004Khan, OFitzgerald, JField, MSoomro, IBeggs, FMorgan, WDuffy, J BACKGROUND: The histologic determinants of survival after surgical resection of stage II nonsmall cell lung cancer are poorly understood. We analyzed the prognostic significance of a number of histologic features after complete resection of T1-2N1M0 nonsmall cell cancer of the lung. METHODS: The case notes and histology of all patients who underwent a potentially curative surgical resection for T1-2N1M0 nonsmall cell carcinoma of the lung between 1991 and 1997 were reviewed retrospectively. The following histologic factors were recorded: histologic type of tumor; number of nodes with metastatic deposits together with their nodal station; the presence of vascular invasion, visceral pleural involvement, and cellular necrosis; and grade of tumor. The results from 98 patients were analyzed. Univariate and multivariate analyses were performed to identify prognostic factors. RESULTS: Univariate analysis showed that only three factors had a statistically significant correlation with a poor prognosis: vascular invasion (p = 0.002), nonsquamous histology (p = 0.005), and visceral pleural involvement (p = 0.002). Multivariate analysis revealed that all three factors were significant independent adverse prognostic indicators. CONCLUSIONS: Visceral pleural involvement, nonsquamous histology, and vascular invasion are all significant adverse prognostic factors after surgical resection of T1-2N1M0 nonsmall cell cancer of the lung. These findings conflict with previously published reports, and we advocate a prospective, large-scale study in order to clarify the prognostic significance of histologic characteristics in stage II disease. |
| spellingShingle | Khan, O Fitzgerald, J Field, M Soomro, I Beggs, F Morgan, W Duffy, J Histological determinants of survival in completely resected T1-2N1M0 nonsmall cell cancer of the lung. |
| title | Histological determinants of survival in completely resected T1-2N1M0 nonsmall cell cancer of the lung. |
| title_full | Histological determinants of survival in completely resected T1-2N1M0 nonsmall cell cancer of the lung. |
| title_fullStr | Histological determinants of survival in completely resected T1-2N1M0 nonsmall cell cancer of the lung. |
| title_full_unstemmed | Histological determinants of survival in completely resected T1-2N1M0 nonsmall cell cancer of the lung. |
| title_short | Histological determinants of survival in completely resected T1-2N1M0 nonsmall cell cancer of the lung. |
| title_sort | histological determinants of survival in completely resected t1 2n1m0 nonsmall cell cancer of the lung |
| work_keys_str_mv | AT khano histologicaldeterminantsofsurvivalincompletelyresectedt12n1m0nonsmallcellcancerofthelung AT fitzgeraldj histologicaldeterminantsofsurvivalincompletelyresectedt12n1m0nonsmallcellcancerofthelung AT fieldm histologicaldeterminantsofsurvivalincompletelyresectedt12n1m0nonsmallcellcancerofthelung AT soomroi histologicaldeterminantsofsurvivalincompletelyresectedt12n1m0nonsmallcellcancerofthelung AT beggsf histologicaldeterminantsofsurvivalincompletelyresectedt12n1m0nonsmallcellcancerofthelung AT morganw histologicaldeterminantsofsurvivalincompletelyresectedt12n1m0nonsmallcellcancerofthelung AT duffyj histologicaldeterminantsofsurvivalincompletelyresectedt12n1m0nonsmallcellcancerofthelung |