Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency.
Ionizing radiation induces clustered DNA damage, which presents a challenge to the cellular repair machinery. The repair efficiency of a single-strand break (SSB) is approximately 4x less than that for repair of an abasic (AP) site when in a bistranded cluster containing 8-oxoG. To explore whether t...
প্রধান লেখক: | Mourgues, S, Lomax, M, O'Neill, P |
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বিন্যাস: | Journal article |
ভাষা: | English |
প্রকাশিত: |
2007
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অনুরূপ উপাদানগুলি
অনুরূপ উপাদানগুলি
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Efficiency of repair of an abasic site within DNA clustered damage sites by mammalian cell nuclear extracts.
অনুযায়ী: Lomax, M, অন্যান্য
প্রকাশিত: (2004) -
8-OxoG retards the activity of the ligase III/XRCC1 complex during the repair of a single-strand break, when present within a clustered DNA damage site.
অনুযায়ী: Lomax, M, অন্যান্য
প্রকাশিত: (2004) -
5,6-Dihydrothymine impairs the base excision repair pathway of a closely opposed AP site or single-strand break.
অনুযায়ী: Byrne, S, অন্যান্য
প্রকাশিত: (2009) -
An oxidized abasic lesion inhibits base excision repair leading to DNA strand breaks in a trinucleotide repeat tract.
অনুযায়ী: Jill M Beaver, অন্যান্য
প্রকাশিত: (2018-01-01) -
Repair of abasic sites in DNA.
অনুযায়ী: Dianov, G, অন্যান্য
প্রকাশিত: (2003)