Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency.

Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency.

Ionizing radiation induces clustered DNA damage, which presents a challenge to the cellular repair machinery. The repair efficiency of a single-strand break (SSB) is approximately 4x less than that for repair of an abasic (AP) site when in a bistranded cluster containing 8-oxoG. To explore whether t...

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Bibliografiska uppgifter
Huvudupphovsmän:	Mourgues, S, Lomax, M, O'Neill, P
Materialtyp:	Journal article
Språk:	English
Publicerad:	2007

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