Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma.

Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma.

Angiogenesis is not only dependent on endothelial cell invasion and proliferation, it also requires pericyte coverage of vascular sprouts for stabilization of vascular walls. Clinical efficacy of angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signaling pathway is sti...

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Dades bibliogràfiques
Autors principals:	Helfrich, I, Scheffrahn, I, Bartling, S, Weis, J, von Felbert, V, Middleton, M, Kato, M, Ergün, S, Augustin, H, Schadendorf, D
Format:	Journal article
Idioma:	English
Publicat:	2010

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