Three-dimensional analysis of budding sites and released virus suggests a revised model for HIV-1 morphogenesis.
Current models of HIV-1 morphogenesis hold that newly synthesized viral Gag polyproteins traffic to and assemble at the cell membrane into spherical protein shells. The resulting late-budding structure is thought to be released by the cellular ESCRT machinery severing the membrane tether connecting...
Main Authors: | Carlson, L, Briggs, J, Glass, B, Riches, J, Simon, M, Johnson, M, Müller, B, Grünewald, K, Kräusslich, H |
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Format: | Journal article |
Language: | English |
Published: |
2008
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