A tidal lung simulation to quantify lung heterogeneity with the Inspired Sinewave Test
We have created a lung simulation to quantify lung heterogeneity from the results of the inspired sinewave test (IST). The IST is a lung function test that is non-invasive, non-ionising and does not require patients' cooperation. A tidal lung simulation is developed to assess this test and also...
| Main Authors: | , , , , |
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| Format: | Conference item |
| Language: | English |
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IEEE Xplore
2020
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| _version_ | 1826279885393362944 |
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| author | Tran, MC Crockett, DC Phan, PA Payne, SJ Farmery, AD |
| author_facet | Tran, MC Crockett, DC Phan, PA Payne, SJ Farmery, AD |
| author_sort | Tran, MC |
| collection | OXFORD |
| description | We have created a lung simulation to quantify lung heterogeneity from the results of the inspired sinewave test (IST). The IST is a lung function test that is non-invasive, non-ionising and does not require patients' cooperation. A tidal lung simulation is developed to assess this test and also a method is proposed to calculate lung heterogeneity from IST results. A sensitivity analysis based on the Morris method and linear regression were applied to verify and to validate the simulation. Additionally, simulated emphysema and pulmonary embolism conditions were created using the simulation to assess the ability of the IST to identify these conditions. Experimental data from five pigs (pre-injured vs injured) were used for validation. This paper contributes to the development of the IST. Firstly, our sensitivity analysis reveals that the IST is highly accurate with an underestimation of about 5% of the simulated values. Sensitivity analysis suggested that both instability in tidal volume and extreme expiratory flow coefficients during the test cause random errors in the IST results. Secondly, the ratios of IST results obtained at two tracer gas oscillation frequencies can identify lung heterogeneity (ELV60/ELV180 and Qp60/Qp180). There was dissimilarity between simulated emphysema and pulmonary embolism (p < 0.0001). In the animal model, the control group had ELV60/ELV180 = 0.58 compared with 0.39 in injured animals (p < 0.0001). |
| first_indexed | 2024-03-07T00:05:29Z |
| format | Conference item |
| id | oxford-uuid:7764a61e-525b-4798-9ef5-a91d703f45f3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:05:29Z |
| publishDate | 2020 |
| publisher | IEEE Xplore |
| record_format | dspace |
| spelling | oxford-uuid:7764a61e-525b-4798-9ef5-a91d703f45f32022-03-26T20:23:44ZA tidal lung simulation to quantify lung heterogeneity with the Inspired Sinewave TestConference itemhttp://purl.org/coar/resource_type/c_5794uuid:7764a61e-525b-4798-9ef5-a91d703f45f3EnglishSymplectic ElementsIEEE Xplore2020Tran, MCCrockett, DCPhan, PAPayne, SJFarmery, ADWe have created a lung simulation to quantify lung heterogeneity from the results of the inspired sinewave test (IST). The IST is a lung function test that is non-invasive, non-ionising and does not require patients' cooperation. A tidal lung simulation is developed to assess this test and also a method is proposed to calculate lung heterogeneity from IST results. A sensitivity analysis based on the Morris method and linear regression were applied to verify and to validate the simulation. Additionally, simulated emphysema and pulmonary embolism conditions were created using the simulation to assess the ability of the IST to identify these conditions. Experimental data from five pigs (pre-injured vs injured) were used for validation. This paper contributes to the development of the IST. Firstly, our sensitivity analysis reveals that the IST is highly accurate with an underestimation of about 5% of the simulated values. Sensitivity analysis suggested that both instability in tidal volume and extreme expiratory flow coefficients during the test cause random errors in the IST results. Secondly, the ratios of IST results obtained at two tracer gas oscillation frequencies can identify lung heterogeneity (ELV60/ELV180 and Qp60/Qp180). There was dissimilarity between simulated emphysema and pulmonary embolism (p < 0.0001). In the animal model, the control group had ELV60/ELV180 = 0.58 compared with 0.39 in injured animals (p < 0.0001). |
| spellingShingle | Tran, MC Crockett, DC Phan, PA Payne, SJ Farmery, AD A tidal lung simulation to quantify lung heterogeneity with the Inspired Sinewave Test |
| title | A tidal lung simulation to quantify lung heterogeneity with the Inspired Sinewave Test |
| title_full | A tidal lung simulation to quantify lung heterogeneity with the Inspired Sinewave Test |
| title_fullStr | A tidal lung simulation to quantify lung heterogeneity with the Inspired Sinewave Test |
| title_full_unstemmed | A tidal lung simulation to quantify lung heterogeneity with the Inspired Sinewave Test |
| title_short | A tidal lung simulation to quantify lung heterogeneity with the Inspired Sinewave Test |
| title_sort | tidal lung simulation to quantify lung heterogeneity with the inspired sinewave test |
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