[18F]fluorination of an arylboronic ester using [18F]selectfluor bis(triflate): application to 6-[18F]fluoro-L-DOPA.

[18F]fluorination of an arylboronic ester using [18F]selectfluor bis(triflate): application to 6-[18F]fluoro-L-DOPA.

The Ag-mediated electrophilic [(18)F]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [(18)F]selectfluor bis(triflate) in acetone. The process gave 6-[(18)F]fluoro-L-DOPA with a RCY of 19 ± 12% and a specific activity of 2.6 ± 0.3 GBq μmol(-1).

Bibliographic Details
Main Authors:	Stenhagen, I, Kirjavainen, A, Forsback, S, Jørgensen, C, Robins, E, Luthra, S, Solin, O, Gouverneur, V
Format:	Journal article
Language:	English
Published:	2013

Similar Items

Fluorination of an arylboronic ester using [18F]selectfluor bis(triflate): Application to 6-[18F]fluoro-l-DOPA
by: Stenhagen, I, et al.
Published: (2013)

Radiosynthesis and evaluation of [18F]Selectfluor bis(triflate).
by: Teare, H, et al.
Published: (2010)

Optimizing the radiosynthesis of 6-[F-18]FDOPA using [F-18]Selectfluor
by: Forsback, S, et al.
Published: (2013)

Advances in the automated synthesis of 6-[18F]Fluoro-L-DOPA
by: Ângela C. B. Neves, et al.
Published: (2021-03-01)

Correction to: Advances in the automated synthesis of 6-[18F]Fluoro-L-DOPA
by: Ângela C. B. Neves, et al.
Published: (2021-05-01)

Synthesis and reactivity of [18F]-N-fluorobenzenesulfonimide
by: Teare, H, et al.
Published: (2007)

Synthesis and reactivity of [18F]-N-fluorobenzenesulfonimide.
by: Teare, H, et al.
Published: (2007)

Fluorous synthesis of 18F radiotracers with the [18F]fluoride ion: nucleophilic fluorination as the detagging process.
by: Bejot, R, et al.
Published: (2009)

Fully automated 18F-fluorination of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) for indirect labelling of nanobodies
by: Surasa Nagachinta, et al.
Published: (2022-11-01)

Effects of Photons Irradiation on 18F-FET and 18F-DOPA Uptake by T98G Glioblastoma Cells
by: Francesca Pasi, et al.
Published: (2020-11-01)

Improved GMP-compliant multi-dose production and quality control of 6-[18F]fluoro-L-DOPA
by: G. Luurtsema, et al.
Published: (2016-04-01)

New methods for the construction of C-18F bonds
by: Stenhagen, I
Published: (2014)

Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin
by: Takayuki Ohkubo, et al.
Published: (2021-07-01)

Metal-free oxidative fluorination of phenols with [18F]fluoride.
by: Gao, Z, et al.
Published: (2012)

Radiosynthesis of 5-[<sup>18</sup>F]Fluoro-1,2,3-triazoles through Aqueous Iodine–[<sup>18</sup>F]Fluorine Exchange Reaction
by: Xiang Zhang, et al.
Published: (2021-09-01)

Optimal 18F-fluorination conditions for the high radiochemical yield of [18F]AlF-NOTA-NHS complexes
by: Hassan, Hishar, et al.
Published: (2021)

Fluorine-18 Labeled Fluorofuranylnorprogesterone ([<sup>18</sup>F]FFNP) and Dihydrotestosterone ([<sup>18</sup>F]FDHT) Prepared by “Fluorination on Sep-Pak” Method
by: Falguni Basuli, et al.
Published: (2019-06-01)

A general copper-mediated nucleophilic 18F fluorination of arenes
by: Tredwell, M, et al.
Published: (2014)

A general copper-mediated nucleophilic 18F fluorination of arenes.
by: Tredwell, M, et al.
Published: (2014)

Convergent 18F Radiosynthesis
by: Gouverneur, V, et al.
Published: (2012)

18F labeling of arenes.
by: Tredwell, M, et al.
Published: (2012)

PET F-18-CHEMISTRY
by: Tredwell, M, et al.
Published: (2011)

Radiosynthesis and Tumor MicroPET/CT Imaging of 18F-Fluoroethoxylerianin, an 18F-Labeled Erianin Analogue
by: Hui Nie, et al.
Published: (2022-04-01)

TMSOTf assisted synthesis of 2'-deoxy-2'-[18F]fluoro-β-D-arabinofuranosylcytosine ([18F]FAC).
by: Kishore K Gangangari, et al.
Published: (2018-01-01)

Transition metals for 19F chemistry and 18F radiochemistry
by: Gouverneur, V
Published: (2013)

18F-radiolabeling of aryl derivatives
by: Gouverneur, V
Published: (2012)

[18F]Fluoride uptake in various bone types and soft tissues in rat
by: Nina Savisto, et al.
Published: (2023-03-01)

18F-trifluoromethylation of unmodified peptides with 5-18F-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate
by: Verhoog, S, et al.
Published: (2018)

Pancreatic uptake and radiation dosimetry of 6-[18F]fluoro-L-DOPA from PET imaging studies in infants with congenital hyperinsulinism.
by: Pradeep K Garg, et al.
Published: (2017-01-01)

Closing the gap between 19F and 18F chemistry
by: Ajenjo, J, et al.
Published: (2021)

Closing the gap between 19F and 18F chemistry
by: Javier Ajenjo, et al.
Published: (2021-09-01)

Derisking the Cu-mediated (18)F-fluorination of heterocyclic positron emission tomography radioligands
by: Taylor, N, et al.
Published: (2017)

Silicon-[18F]Fluorine Radiochemistry: Basics, Applications and Challenges
by: Carmen Wängler, et al.
Published: (2012-03-01)

Positron emission tomography in ovarian cancer: 18F-deoxy-glucose and 16α-18F-fluoro-17β-estradiol PET
by: Yoshida Yoshio, et al.
Published: (2009-06-01)

GMP production of 6-[18F]Fluoro-l-DOPA for PET/CT imaging by different synthetic routes: a three center experience
by: Valdemar L. Andersen, et al.
Published: (2021-06-01)

Use of static and dynamic [18F]-F-DOPA PET parameters for detecting patients with glioma recurrence or progression
by: Timothée Zaragori, et al.
Published: (2020-05-01)

Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride
by: Sap, J, et al.
Published: (2019)

Correction to: Closing the gap between 19F and 18F chemistry
by: Javier Ajenjo, et al.
Published: (2022-01-01)

Prognostic impact of [18F]fluorothymidine and [18F]fluoro-D-glucose baseline uptakes in patients with lung cancer treated first-line with erlotinib.
by: Matthias Scheffler, et al.
Published: (2013-01-01)

[18F]Tosyl fluoride as a versatile [18F]fluoride source for the preparation of 18F-labeled radiopharmaceuticals
by: Dong Zhou, et al.
Published: (2023-02-01)