Genetic effects on an animal model of anxiety.
Genetic effects on behavioural measures thought to model anxiety have been reported on 15 mouse chromosomes. In general the individual effect from each locus is small, contributing to 10% or less of the total variation, but through use of crosses between inbred rodents the power to detect such effec...
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| Format: | Journal article |
| Language: | English |
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2002
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| _version_ | 1797076590551629824 |
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| author | Flint, J |
| author_facet | Flint, J |
| author_sort | Flint, J |
| collection | OXFORD |
| description | Genetic effects on behavioural measures thought to model anxiety have been reported on 15 mouse chromosomes. In general the individual effect from each locus is small, contributing to 10% or less of the total variation, but through use of crosses between inbred rodents the power to detect such effects is high: 39 loci have been reported at stringent levels of significance. Novel multivariate analyses of these data go some way to characterizing the genetic architecture of anxiety and also to validating the tests that are used for its measurement. However, we are still some way from finding the molecular variants that explain the heritability of the trait. |
| first_indexed | 2024-03-07T00:05:51Z |
| format | Journal article |
| id | oxford-uuid:7783b248-7742-49bf-b1f9-46b65e38e6a6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:05:51Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:7783b248-7742-49bf-b1f9-46b65e38e6a62022-03-26T20:24:33ZGenetic effects on an animal model of anxiety.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7783b248-7742-49bf-b1f9-46b65e38e6a6EnglishSymplectic Elements at Oxford2002Flint, JGenetic effects on behavioural measures thought to model anxiety have been reported on 15 mouse chromosomes. In general the individual effect from each locus is small, contributing to 10% or less of the total variation, but through use of crosses between inbred rodents the power to detect such effects is high: 39 loci have been reported at stringent levels of significance. Novel multivariate analyses of these data go some way to characterizing the genetic architecture of anxiety and also to validating the tests that are used for its measurement. However, we are still some way from finding the molecular variants that explain the heritability of the trait. |
| spellingShingle | Flint, J Genetic effects on an animal model of anxiety. |
| title | Genetic effects on an animal model of anxiety. |
| title_full | Genetic effects on an animal model of anxiety. |
| title_fullStr | Genetic effects on an animal model of anxiety. |
| title_full_unstemmed | Genetic effects on an animal model of anxiety. |
| title_short | Genetic effects on an animal model of anxiety. |
| title_sort | genetic effects on an animal model of anxiety |
| work_keys_str_mv | AT flintj geneticeffectsonananimalmodelofanxiety |