Human melanoma cells expressing V600E B-RAF are susceptible to IGF1R targeting by small interfering RNAs.

Human melanoma cells expressing V600E B-RAF are susceptible to IGF1R targeting by small interfering RNAs.

The type 1 insulin-like growth factor receptor (IGF1R) is overexpressed by malignant melanomas compared with benign naevi, and mediates proliferation, motility and protection from apoptosis. However, the utility of IGF1R targeting as anti-cancer therapy may be limited by activating mutations in down...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Yeh, A, Bohula, E, Macaulay, V
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2006

समान संसाधन

The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript.
द्वारा: Bohula, E, और अन्य
प्रकाशित: (2003)

Small molecules against B-RAF (BRAF) Val600Glu (V600E) single mutation
द्वारा: Zaharie F, और अन्य
प्रकाशित: (2015-07-01)

Critical role of miR-10b in B-RafV600E dependent anchorage independent growth and invasion of melanoma cells.
द्वारा: Ila Datar, और अन्य
प्रकाशित: (2019-01-01)

Activation mechanisms of clinically distinct B‐Raf V600E and V600K mutants
द्वारा: Mingzhen Zhang, और अन्य
प्रकाशित: (2023-03-01)

A simple and cost-effective method for producing small interfering RNAs with high efficacy.
द्वारा: Sohail, M, और अन्य
प्रकाशित: (2003)

A simple and cost-effective method for producing small interfering RNAs with high efficacy.
द्वारा: Sohail, M, और अन्य
प्रकाशित: (2003)

Analysis of microRNAs, phased small interfering RNAs and their potential targets in Rosa rugosa Thunb.
द्वारा: Junqiang Guo, और अन्य
प्रकाशित: (2019-04-01)

Phased secondary small interfering RNAs in Panaxnotoginseng
द्वारा: Kun Chen, और अन्य
प्रकाशित: (2018-01-01)

Differential sensitivity of melanoma cell lines with <it>BRAF</it><sup><it>V600E </it></sup>mutation to the specific Raf inhibitor PLX4032
द्वारा: Kehoe Sarah M, और अन्य
प्रकाशित: (2010-04-01)

Imidazothiazole-based potent inhibitors of V600E-B-RAF kinase with promising anti-melanoma activity: biological and computational studies
द्वारा: Hanan S. Anbar, और अन्य
प्रकाशित: (2020-01-01)

Identifying Cleaved and Noncleaved Targets of Small Interfering RNAs and MicroRNAs in Mammalian Cells by SpyCLIP
द्वारा: Yao Zhang, और अन्य
प्रकाशित: (2020-12-01)

Viral small interfering RNAs target host genes to mediate disease symptoms in plants.
द्वारा: Neil A Smith, और अन्य
प्रकाशित: (2011-05-01)

The IGF receptor as anticancer treatment target.
द्वारा: Macaulay, V
प्रकाशित: (2004)

Targeting the IGF receptor as treatment for cancer
द्वारा: Macaulay, V
प्रकाशित: (2007)

Therapeutic targeting of the IGF axis
द्वारा: Osher, E, और अन्य
प्रकाशित: (2019)

PL6 biology of the IGF1R
द्वारा: Macaulay, V
प्रकाशित: (2008)

Therapeutic Targeting of the IGF Axis
द्वारा: Eliot Osher, और अन्य
प्रकाशित: (2019-08-01)

An Integrative Analysis Of The Micro-RNAs Contributing In Stemness, Metastasis And B-Raf Pathways In Malignant Melanoma And Melanoma Stem Cell
द्वारा: Parisa Sahranavardfard, और अन्य
प्रकाशित: (2021-08-01)

Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion.
द्वारा: Boyd, S, और अन्य
प्रकाशित: (2013)

Oncogenic B-RAF V600E signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion
द्वारा: Boyd, S, और अन्य
प्रकाशित: (2013)

Determining the defining lengths between mature microRNAs/small interfering RNAs and tinyRNAs
द्वारा: GeunYoung Sim, और अन्य
प्रकाशित: (2023-11-01)

Effect of small interfering RNAs on matrix metalloproteinase 1 expression
द्वारा: Gen-Hung Chen, और अन्य
प्रकाशित: (2014-12-01)

Development of therapeutic-grade small interfering RNAs by chemical engineering
द्वारा: Jesper Bertram Bramsen, और अन्य
प्रकाशित: (2012-08-01)

Electroporation of Small Interfering RNAs into Tibialis Anterior Muscles of Mice
द्वारा: Anna Stephan, और अन्य
प्रकाशित: (2022-06-01)

Tospoviruses Induce Small Interfering RNAs Targeting Viral Sequences and Endogenous Transcripts in Solanaceous Plants
द्वारा: Stephen J. Fletcher, और अन्य
प्रकाशित: (2022-06-01)

A Comprehensive Review of Small Interfering RNAs (siRNAs): Mechanism, Therapeutic Targets, and Delivery Strategies for Cancer Therapy
द्वारा: Zhang J, और अन्य
प्रकाशित: (2023-12-01)

IGF1R INHIBITORS: RATIONAL COMBINATORIAL STRATEGIES
द्वारा: Macaulay, V
प्रकाशित: (2010)

Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A – C-Raf
द्वारा: Connor M. Blair, और अन्य
प्रकाशित: (2019-03-01)

IGF1R signalling and its inhibition.
द्वारा: Riedemann, J, और अन्य
प्रकाशित: (2006)

Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach
द्वारा: Mahmoodi Chalbatani G, और अन्य
प्रकाशित: (2019-05-01)

Heat‐responsive microRNAs and phased small interfering RNAs in reproductive development of flax
द्वारा: Suresh Pokhrel, और अन्य
प्रकाशित: (2022-02-01)

Fast reaction and long duration—application of dabrafenib plus trametinib in treatment of metastatic melanoma with B-Raf V600E mutation: A case report
द्वारा: Yang Yang, और अन्य
प्रकाशित: (2021-12-01)

IGF2 and IGF1R mRNAs Are Detectable in Human Spermatozoa
द्वारा: Rossella Cannarella, और अन्य
प्रकाशित: (2020-10-01)

Development and in vivo validation of small interfering RNAs targeting NOX3 to prevent sensorineural hearing loss
द्वारा: German Nacher-Soler, और अन्य
प्रकाशित: (2022-09-01)

Effects of small interfering RNAs targeting fascin on human esophageal squamous cell carcinoma cell lines
द्वारा: Garcia Jose, और अन्य
प्रकाशित: (2010-06-01)

Development of molecular agents for IGF receptor targeting.
द्वारा: Salisbury, A, और अन्य
प्रकाशित: (2003)

Expression of B-type RAF V600E in Thyroid Carcinoma and its Association with Histological Type
द्वारा: Sonia Kumari, और अन्य
प्रकाशित: (2021-08-01)

Targeting the type 1 insulin-like growth factor receptor as anti-cancer treatment.
द्वारा: Bohula, E, और अन्य
प्रकाशित: (2003)

Small interfering RNA targeted to IGF-IR delays tumor growth and induces proinflammatory cytokines in a mouse breast cancer model.
द्वारा: Tiphanie Durfort, और अन्य
प्रकाशित: (2012-01-01)

IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide
द्वारा: Ramcharan, R, और अन्य
प्रकाशित: (2015)