FLT3-ITDs Introduce a Myeloid Differentiation and Transformation Bias to Multipotent Lympho-Myeloid Progenitors

FLT3-ITDs Introduce a Myeloid Differentiation and Transformation Bias to Multipotent Lympho-Myeloid Progenitors

Bibliographic Details
Main Authors:	Mead, A, Kharazi, S, Macaulay, I, Atkinson, D, Loughran, S, Lutteropp, M, Woll, P, Luc, S, Buza-Vidas, N, Ferry, H, Nerlov, C, Sitnicka, E, Jacobsen, S
Format:	Conference item
Published:	2011

Similar Items

FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors.
by: Mead, A, et al.
Published: (2013)

FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells.
by: Buza-Vidas, N, et al.
Published: (2011)

ESTABLISHMENT OF LYMPHO-MYELOID RESTRICTED PROGENITORS PRIOR TO THE EMERGENCE OF DEFINITIVE HEMATOPOIETIC STEM CELLS
by: Boiers, C, et al.
Published: (2013)

Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors
by: Luis, T, et al.
Published: (2016)

Embryonic thymopoiesis is initiated by an immune-restricted lympho-myeloid progenitor independently of notch signaling
by: Luis, T, et al.
Published: (2016)

Distinct myeloid progenitor differentiation pathways identified through single cell RNA sequencing
by: Drissen, R, et al.
Published: (2016)

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.
by: Kharazi, S, et al.
Published: (2011)

Biological and molecular evidence for existence of lymphoid-primed multipotent progenitors.
by: Luc, S, et al.
Published: (2007)

FLT3-ITD INDUCED MYELOPROLIFERATION CAUSES A CELL EXTRINSIC DEPLETION OF HAEMATOPOIETIC STEM CELLS
by: Mead, A, et al.
Published: (2014)

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.
by: Luc, S, et al.
Published: (2012)

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential
by: Luc, S, et al.
Published: (2012)

Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.
by: Böiers, C, et al.
Published: (2010)

ROLE OF BIALLELIC C/EBPALPHA MUTATIONS AND FLT-3 ITD IN INITIATION AND MAINTENANCE OF AML
by: Reckzeh, K, et al.
Published: (2010)

Ezh2 and Runx1 mutations collaborate to initiate lympho-myeloid leukemia in early thymic progenitors
by: Booth, CAG, et al.
Published: (2018)

Characterising early human lympho-myeloid haematopoietic progenitors and their relationship with acute myeloid leukaemia stem cells
by: Aboukhalil, Z
Published: (2018)

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential
by: Luc, S, et al.
Published: (2012)

Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells.
by: Karamitros, D, et al.
Published: (2017)

How ITD Insertion Sites Orchestrate the Biology and Disease of FLT3-ITD-Mutated Acute Myeloid Leukemia
by: Tobias R. Haage, et al.
Published: (2023-05-01)

Gab2 is Essential for Transformation by FLT3-ITD in Acute Myeloid Leukemia
by: Katharina Sies, et al.
Published: (2019-04-01)

Downregulation of Mpl marks the transition to lymphoid-primed multipotent progenitors with gradual loss of granulocyte-monocyte potential
by: Luc, S, et al.
Published: (2007)

Autophagy activation mediates resistance to FLT3 inhibitors in acute myeloid leukemia with FLT3-ITD mutation
by: Dan Xu, et al.
Published: (2022-07-01)

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD–induced myeloproliferation
by: Mead, A, et al.
Published: (2017)

NPM1 and FLT3-ITD/TKD Gene Mutations in Acute Myeloid Leukemia
by: Shano Naseem, et al.
Published: (2021-01-01)

Gilteritinib as treatment for extra-medullary relapse of FLT3-ITD acute myeloid leukemia FLT3-ITD, after allogeneic haematopoietic stem cell transplantation
by: R. Iannotta, et al.
Published: (2022-01-01)

Single cell assays unveil functional and transcriptional heterogeneity of human hemopoietic lympho-myeloid progenitors
by: Stoilova, B, et al.
Published: (2017)

<i>Zeb1</i> Regulates the Function of Lympho-Myeloid Primed Progenitors after Transplantation
by: Alhomidi Almotiri, et al.
Published: (2023-09-01)

Down-regulation of Mpl marks the transition to lymphoid-primed multipotent progenitors with gradual loss of granulocyte-monocyte potential.
by: Luc, S, et al.
Published: (2008)

Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate.
by: Grover, A, et al.
Published: (2014)

Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia
by: Bai‐Liang He, et al.
Published: (2020-08-01)

PB1856: MUTATION STATUS AND ALLELE BURDEN OF FLT3-ITD IN ACUTE MYELOID LEUKEMIA
by: Asiyat Radzhabova, et al.
Published: (2023-08-01)

Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia
by: Bai‐Liang He, et al.
Published: (2020-04-01)

NADPH oxidase mediated oxidative stress signaling in FLT3-ITD acute myeloid leukemia
by: Yongfeng Chen, et al.
Published: (2023-06-01)

Eccentricity of Acute Myeloid Leukemia with NPM1 and FLT3-ITD mutation: a case report
by: Nur Zainura Mohamad,, et al.
Published: (2022)

The Potential Transcriptomic and Metabolomic Mechanisms of ATO and ATRA in Treatment of FLT3-ITD Acute Myeloid Leukemia
by: Chun-Jin Peng MD, et al.
Published: (2024-01-01)

GNF-7, a novel FLT3 inhibitor, overcomes drug resistance for the treatment of FLT3‑ITD acute myeloid leukemia
by: Xinhua Xiao, et al.
Published: (2023-11-01)

A novel model of human lympho-myeloid progenitor hierarchy based on single cell functional and transcriptional analysis
by: Karamitros, D, et al.
Published: (2017)

A novel model of human hemopoiesis based on single cell functional and transcriptional analysis of lympho-myeloid progenitors
by: Stoilova, B, et al.
Published: (2017)

Stem cell biology is population biology: differentiation of hematopoietic multipotent progenitors to common lymphoid and myeloid progenitors.
by: Mangel, M, et al.
Published: (2013)

FLT3 receptor and ligand are dispensable for maintenance and posttransplantation expansion of mouse hematopoietic stem cells.
by: Buza-Vidas, N, et al.
Published: (2009)

FLT3‐targeted therapy restores GATA1 pathway function in NPM1/FLT3‐ITD mutated acute myeloid leukaemia
by: D Sorcini, et al.
Published: (2023-11-01)