Neurophysiological and behavioural investigation of the auditory cortico-collicular pathway
One of the key objectives in neuroscience is to understand how the brain processes sensory information to generate perception and guide decisions. Sensory processing has been studied extensively, primarily from a hierarchical perspective with a focus on the processing along ascending pathways. Howev...
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| Format: | Thesis |
| Language: | English |
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2022
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| _version_ | 1797110064757080064 |
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| author | Lee, T-Y |
| author2 | King, A |
| author_facet | King, A Lee, T-Y |
| author_sort | Lee, T-Y |
| collection | OXFORD |
| description | One of the key objectives in neuroscience is to understand how the brain processes sensory information to generate perception and guide decisions. Sensory processing has been studied extensively, primarily from a hierarchical perspective with a focus on the processing along ascending pathways. However, ascending sensory pathways are accompanied by descending connections at various levels of processing, yet their contributions to sensory processing remain unclear. In this thesis, I studied one of the major descending circuits in the central auditory system, the cortico-collicular pathway, which connects the auditory cortex (AC) to the auditory midbrain (i.e. the inferior colliculus, IC). To understand the role of this pathway during sound-guided behaviour, I used two-photon calcium imaging to measure the activity of neurons in the IC that receive projections from the AC while manipulating the AC inputs during a sound detection task. I found that individual cortico-recipient inferior colliculus (CRIC) neurons exhibited heterogeneous patterns of activity, and that the AC appears to be involved in influencing some of these patterns. Further, I showed that the CRIC trial-by-trial network activity contained behaviourally-relevant information, and that this information was more unreliable when the AC input was removed. Overall, this work offers novel insights into the neural and behavioural function of the auditory cortico-collicular pathway, which contributes to our understanding of the role of descending sensory pathways in perception and behaviour. |
| first_indexed | 2024-03-07T07:50:01Z |
| format | Thesis |
| id | oxford-uuid:77d5cd9b-4349-4877-9092-9850b5f033da |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:50:01Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | oxford-uuid:77d5cd9b-4349-4877-9092-9850b5f033da2023-07-05T09:26:03ZNeurophysiological and behavioural investigation of the auditory cortico-collicular pathwayThesishttp://purl.org/coar/resource_type/c_db06uuid:77d5cd9b-4349-4877-9092-9850b5f033daNeurophysiologyNeurosciencesEnglishHyrax Deposit2022Lee, T-YKing, ADahmen, JOne of the key objectives in neuroscience is to understand how the brain processes sensory information to generate perception and guide decisions. Sensory processing has been studied extensively, primarily from a hierarchical perspective with a focus on the processing along ascending pathways. However, ascending sensory pathways are accompanied by descending connections at various levels of processing, yet their contributions to sensory processing remain unclear. In this thesis, I studied one of the major descending circuits in the central auditory system, the cortico-collicular pathway, which connects the auditory cortex (AC) to the auditory midbrain (i.e. the inferior colliculus, IC). To understand the role of this pathway during sound-guided behaviour, I used two-photon calcium imaging to measure the activity of neurons in the IC that receive projections from the AC while manipulating the AC inputs during a sound detection task. I found that individual cortico-recipient inferior colliculus (CRIC) neurons exhibited heterogeneous patterns of activity, and that the AC appears to be involved in influencing some of these patterns. Further, I showed that the CRIC trial-by-trial network activity contained behaviourally-relevant information, and that this information was more unreliable when the AC input was removed. Overall, this work offers novel insights into the neural and behavioural function of the auditory cortico-collicular pathway, which contributes to our understanding of the role of descending sensory pathways in perception and behaviour. |
| spellingShingle | Neurophysiology Neurosciences Lee, T-Y Neurophysiological and behavioural investigation of the auditory cortico-collicular pathway |
| title | Neurophysiological and behavioural investigation of the auditory cortico-collicular pathway |
| title_full | Neurophysiological and behavioural investigation of the auditory cortico-collicular pathway |
| title_fullStr | Neurophysiological and behavioural investigation of the auditory cortico-collicular pathway |
| title_full_unstemmed | Neurophysiological and behavioural investigation of the auditory cortico-collicular pathway |
| title_short | Neurophysiological and behavioural investigation of the auditory cortico-collicular pathway |
| title_sort | neurophysiological and behavioural investigation of the auditory cortico collicular pathway |
| topic | Neurophysiology Neurosciences |
| work_keys_str_mv | AT leety neurophysiologicalandbehaviouralinvestigationoftheauditorycorticocollicularpathway |