Genetic predisposition to type 2 diabetes and risk of subclinical atherosclerosis and cardiovascular diseases among 160,000 Chinese adults
<p style="text-align:justify;">In observational studies, type 2 diabetes is associated with 2- to 4-fold higher risks of cardiovascular diseases (CVD). Using data from the China Kadoorie Biobank, we examined associations of genetically-predicted type 2 diabetes with CVD among ∼160,0...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Diabetes Association
2019
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| _version_ | 1797076671693586432 |
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| author | Gan, W Bragg, F Walters, R Millwood, I Lin, K Chen, Y Guo, Y Vaucher, J Bian, Z Bennett, D Lv, J Yu, C Mahajan, A Clarke, R Li, L Holmes, M McCarthy, M Chen, Z China Kadoorie Biobank Collaborative Group |
| author_facet | Gan, W Bragg, F Walters, R Millwood, I Lin, K Chen, Y Guo, Y Vaucher, J Bian, Z Bennett, D Lv, J Yu, C Mahajan, A Clarke, R Li, L Holmes, M McCarthy, M Chen, Z China Kadoorie Biobank Collaborative Group |
| author_sort | Gan, W |
| collection | OXFORD |
| description | <p style="text-align:justify;">In observational studies, type 2 diabetes is associated with 2- to 4-fold higher risks of cardiovascular diseases (CVD). Using data from the China Kadoorie Biobank, we examined associations of genetically-predicted type 2 diabetes with CVD among ∼160,000 participants, to assess whether these relationships are causal. A type 2 diabetes genetic risk score (comprising 48 established risk variants) was associated with the presence of carotid plaque (OR 1.17 [95% CI 1.05, 1.29] per 1 unit higher log-odds of type 2 diabetes; n=6,819), and elevated risk of ischaemic stroke (IS) (1.08 [1.02, 1.14]; n=17,097), non-lacunar IS (1.09 [1.03, 1.16]; n=13,924) and major coronary event (1.12 [1.02, 1.23]; n= 5,081). There was no significant association with lacunar IS (1.03 [0.91, 1.16], n=3,173) or intracerebral haemorrhage (ICH) (1.01 [0.94, 1.10], n=6,973), although effect estimates were imprecise. These associations were consistent with observational associations of type 2 diabetes with CVD in CKB (p for heterogeneity>0.3), and with the associations of type 2 diabetes with IS, ICH and coronary heart disease in two-sample Mendelian randomisation analyses based on summary statistics from European population GWAS (p for heterogeneity>0.2). In conclusion, among Chinese adults, genetic predisposition to type 2 diabetes was associated with atherosclerotic CVD, consistent with a causal association.</p> |
| first_indexed | 2024-03-07T00:07:03Z |
| format | Journal article |
| id | oxford-uuid:77e3d098-2a9f-4fe9-8252-1707983769c7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:07:03Z |
| publishDate | 2019 |
| publisher | American Diabetes Association |
| record_format | dspace |
| spelling | oxford-uuid:77e3d098-2a9f-4fe9-8252-1707983769c72022-03-26T20:27:14ZGenetic predisposition to type 2 diabetes and risk of subclinical atherosclerosis and cardiovascular diseases among 160,000 Chinese adultsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:77e3d098-2a9f-4fe9-8252-1707983769c7EnglishSymplectic Elements at OxfordAmerican Diabetes Association2019Gan, WBragg, FWalters, RMillwood, ILin, KChen, YGuo, YVaucher, JBian, ZBennett, DLv, JYu, CMahajan, AClarke, RLi, LHolmes, MMcCarthy, MChen, ZChina Kadoorie Biobank Collaborative Group <p style="text-align:justify;">In observational studies, type 2 diabetes is associated with 2- to 4-fold higher risks of cardiovascular diseases (CVD). Using data from the China Kadoorie Biobank, we examined associations of genetically-predicted type 2 diabetes with CVD among ∼160,000 participants, to assess whether these relationships are causal. A type 2 diabetes genetic risk score (comprising 48 established risk variants) was associated with the presence of carotid plaque (OR 1.17 [95% CI 1.05, 1.29] per 1 unit higher log-odds of type 2 diabetes; n=6,819), and elevated risk of ischaemic stroke (IS) (1.08 [1.02, 1.14]; n=17,097), non-lacunar IS (1.09 [1.03, 1.16]; n=13,924) and major coronary event (1.12 [1.02, 1.23]; n= 5,081). There was no significant association with lacunar IS (1.03 [0.91, 1.16], n=3,173) or intracerebral haemorrhage (ICH) (1.01 [0.94, 1.10], n=6,973), although effect estimates were imprecise. These associations were consistent with observational associations of type 2 diabetes with CVD in CKB (p for heterogeneity>0.3), and with the associations of type 2 diabetes with IS, ICH and coronary heart disease in two-sample Mendelian randomisation analyses based on summary statistics from European population GWAS (p for heterogeneity>0.2). In conclusion, among Chinese adults, genetic predisposition to type 2 diabetes was associated with atherosclerotic CVD, consistent with a causal association.</p> |
| spellingShingle | Gan, W Bragg, F Walters, R Millwood, I Lin, K Chen, Y Guo, Y Vaucher, J Bian, Z Bennett, D Lv, J Yu, C Mahajan, A Clarke, R Li, L Holmes, M McCarthy, M Chen, Z China Kadoorie Biobank Collaborative Group Genetic predisposition to type 2 diabetes and risk of subclinical atherosclerosis and cardiovascular diseases among 160,000 Chinese adults |
| title | Genetic predisposition to type 2 diabetes and risk of subclinical atherosclerosis and cardiovascular diseases among 160,000 Chinese adults |
| title_full | Genetic predisposition to type 2 diabetes and risk of subclinical atherosclerosis and cardiovascular diseases among 160,000 Chinese adults |
| title_fullStr | Genetic predisposition to type 2 diabetes and risk of subclinical atherosclerosis and cardiovascular diseases among 160,000 Chinese adults |
| title_full_unstemmed | Genetic predisposition to type 2 diabetes and risk of subclinical atherosclerosis and cardiovascular diseases among 160,000 Chinese adults |
| title_short | Genetic predisposition to type 2 diabetes and risk of subclinical atherosclerosis and cardiovascular diseases among 160,000 Chinese adults |
| title_sort | genetic predisposition to type 2 diabetes and risk of subclinical atherosclerosis and cardiovascular diseases among 160 000 chinese adults |
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