Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.

Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.

The endothelins are a family of endothelium-derived peptides that possess a variety of functions, including vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and promotes myofibroblast contraction and migration, hence contributing to matrix remodeling during tissue repair. H...

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Autors principals:	Shi-Wen, X, Chen, Y, Denton, C, Eastwood, M, Renzoni, E, Bou-Gharios, G, Pearson, J, Dashwood, M, du Bois, R, Black, C, Leask, A, Abraham, D
Format:	Journal article
Idioma:	English
Publicat:	2004

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