Argonaute utilization for miRNA silencing is determined by phosphorylation-dependent recruitment of LIM-domain-containing proteins.

Argonaute utilization for miRNA silencing is determined by phosphorylation-dependent recruitment of LIM-domain-containing proteins.

As core components of the microRNA-induced silencing complex (miRISC), Argonaute (AGO) proteins interact with TNRC6 proteins, recruiting other effectors of translational repression/mRNA destabilization. Here, we show that LIMD1 coordinates the assembly of an AGO-TNRC6 containing miRISC complex by bi...

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Bibliographic Details
Main Authors: Bridge, KS, Shah, KM, Li, Y, Foxler, DE, Wong, SCK, Miller, DC, Davidson, KM, Foster, JG, Rose, R, Hodgkinson, MR, Ribeiro, PS, Aboobaker, AA, Yashiro, K, Wang, X, Graves, PR, Plevin, MJ, Lagos, D, Sharp, TV
Format: Journal article
Language:English
Published: Elsevier 2017

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