Slow Adaptation of Ventricular Repolarization as a Cause of Arrhythmia?
Introduction: This article is part of the Focus Theme of Methods of Information in Medicine on \"Biosignal Interpretation: Advanced Methods for Studying Cardiovascular and Respiratory Systems\". Background: Adaptation of the QT-interval to changes in heart rate reflects on the body-surface...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal article |
| Published: |
2014
|
| _version_ | 1797076707154329600 |
|---|---|
| author | Bueno−Orovio, A Hanson, B Gill, J Taggart, P Rodriguez, B |
| author_facet | Bueno−Orovio, A Hanson, B Gill, J Taggart, P Rodriguez, B |
| author_sort | Bueno−Orovio, A |
| collection | OXFORD |
| description | Introduction: This article is part of the Focus Theme of Methods of Information in Medicine on \"Biosignal Interpretation: Advanced Methods for Studying Cardiovascular and Respiratory Systems\". Background: Adaptation of the QT-interval to changes in heart rate reflects on the body-surface electrocardiogram the adaptation of action potential duration (APD) at the cellular level. The initial fast phase of APD adaptation has been shown to modulate the arrhythmia substrate. Whether the slow phase is potentially proarrhythmic remains unclear. Objectives: To analyze in-vivo human data and use computer simulations to examine effects of the slow APD adaptation phase on dispersion of repolarization and reentry in the human ventricle. Methods: Electrograms were acquired from 10 left and 10 right ventricle (LV/RV) endocardial sites in 15 patients with normal ventricles during RV pacing. Activation-recovery intervals, as a surrogate for APD, were measured during a sustained increase in heart rate. Observed dynamics were studied using computer simulations of human tissue electrophysiology. Results: Spatial heterogeneity of rate adaptation was observed in all patients. Inhomogeneity in slow APD adaptation time constants (Δτs) was greater in LV than RV (ΔτsLV = 31.8 ± 13.2, ΔτsRV = 19.0 ± 12.8 s , P< 0.01). Simulations showed that altering local slow time constants of adaptation was sufficient to convert partial wavefront block to block with successful reentry. Conclusions: Using electrophysiological data acquired in-vivo in human and computer simulations, we identify heterogeneity in the slow phase of APD adaptation as an important component of arrhythmogenesis. |
| first_indexed | 2024-03-07T00:07:35Z |
| format | Journal article |
| id | oxford-uuid:781355ec-27ae-4b96-af13-289e39704b83 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T00:07:35Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:781355ec-27ae-4b96-af13-289e39704b832022-03-26T20:28:20ZSlow Adaptation of Ventricular Repolarization as a Cause of Arrhythmia?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:781355ec-27ae-4b96-af13-289e39704b83Department of Computer Science2014Bueno−Orovio, AHanson, BGill, JTaggart, PRodriguez, BIntroduction: This article is part of the Focus Theme of Methods of Information in Medicine on \"Biosignal Interpretation: Advanced Methods for Studying Cardiovascular and Respiratory Systems\". Background: Adaptation of the QT-interval to changes in heart rate reflects on the body-surface electrocardiogram the adaptation of action potential duration (APD) at the cellular level. The initial fast phase of APD adaptation has been shown to modulate the arrhythmia substrate. Whether the slow phase is potentially proarrhythmic remains unclear. Objectives: To analyze in-vivo human data and use computer simulations to examine effects of the slow APD adaptation phase on dispersion of repolarization and reentry in the human ventricle. Methods: Electrograms were acquired from 10 left and 10 right ventricle (LV/RV) endocardial sites in 15 patients with normal ventricles during RV pacing. Activation-recovery intervals, as a surrogate for APD, were measured during a sustained increase in heart rate. Observed dynamics were studied using computer simulations of human tissue electrophysiology. Results: Spatial heterogeneity of rate adaptation was observed in all patients. Inhomogeneity in slow APD adaptation time constants (Δτs) was greater in LV than RV (ΔτsLV = 31.8 ± 13.2, ΔτsRV = 19.0 ± 12.8 s , P< 0.01). Simulations showed that altering local slow time constants of adaptation was sufficient to convert partial wavefront block to block with successful reentry. Conclusions: Using electrophysiological data acquired in-vivo in human and computer simulations, we identify heterogeneity in the slow phase of APD adaptation as an important component of arrhythmogenesis. |
| spellingShingle | Bueno−Orovio, A Hanson, B Gill, J Taggart, P Rodriguez, B Slow Adaptation of Ventricular Repolarization as a Cause of Arrhythmia? |
| title | Slow Adaptation of Ventricular Repolarization as a Cause of Arrhythmia? |
| title_full | Slow Adaptation of Ventricular Repolarization as a Cause of Arrhythmia? |
| title_fullStr | Slow Adaptation of Ventricular Repolarization as a Cause of Arrhythmia? |
| title_full_unstemmed | Slow Adaptation of Ventricular Repolarization as a Cause of Arrhythmia? |
| title_short | Slow Adaptation of Ventricular Repolarization as a Cause of Arrhythmia? |
| title_sort | slow adaptation of ventricular repolarization as a cause of arrhythmia |
| work_keys_str_mv | AT buenoorovioa slowadaptationofventricularrepolarizationasacauseofarrhythmia AT hansonb slowadaptationofventricularrepolarizationasacauseofarrhythmia AT gillj slowadaptationofventricularrepolarizationasacauseofarrhythmia AT taggartp slowadaptationofventricularrepolarizationasacauseofarrhythmia AT rodriguezb slowadaptationofventricularrepolarizationasacauseofarrhythmia |