Short peptides assist the folding of free class I heavy chains in solution.
Previous experiments have shown that short peptides coresponding to naturally processed epitopes of viral antigens can induce a conformational change in the class I heavy chain (HC) to which they bind in the fully assembled molecule. Here, we present evidence that the mechanism for this conformation...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1992
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| _version_ | 1797076710947028992 |
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| author | Elliott, T Cerundolo, V Townsend, A |
| author_facet | Elliott, T Cerundolo, V Townsend, A |
| author_sort | Elliott, T |
| collection | OXFORD |
| description | Previous experiments have shown that short peptides coresponding to naturally processed epitopes of viral antigens can induce a conformational change in the class I heavy chain (HC) to which they bind in the fully assembled molecule. Here, we present evidence that the mechanism for this conformational change may involve binding of peptide to a partially unfolded form of free HC, followed by its subsequent folding. These results may be important for understanding the way in which class I molecules are assembled in vivo, and how certain epitopes are selected for presentation to T cells. |
| first_indexed | 2024-03-07T00:07:38Z |
| format | Journal article |
| id | oxford-uuid:7818ac1d-8cba-469b-a01a-b537fe9c1e41 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:07:38Z |
| publishDate | 1992 |
| record_format | dspace |
| spelling | oxford-uuid:7818ac1d-8cba-469b-a01a-b537fe9c1e412022-03-26T20:28:24ZShort peptides assist the folding of free class I heavy chains in solution.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7818ac1d-8cba-469b-a01a-b537fe9c1e41EnglishSymplectic Elements at Oxford1992Elliott, TCerundolo, VTownsend, APrevious experiments have shown that short peptides coresponding to naturally processed epitopes of viral antigens can induce a conformational change in the class I heavy chain (HC) to which they bind in the fully assembled molecule. Here, we present evidence that the mechanism for this conformational change may involve binding of peptide to a partially unfolded form of free HC, followed by its subsequent folding. These results may be important for understanding the way in which class I molecules are assembled in vivo, and how certain epitopes are selected for presentation to T cells. |
| spellingShingle | Elliott, T Cerundolo, V Townsend, A Short peptides assist the folding of free class I heavy chains in solution. |
| title | Short peptides assist the folding of free class I heavy chains in solution. |
| title_full | Short peptides assist the folding of free class I heavy chains in solution. |
| title_fullStr | Short peptides assist the folding of free class I heavy chains in solution. |
| title_full_unstemmed | Short peptides assist the folding of free class I heavy chains in solution. |
| title_short | Short peptides assist the folding of free class I heavy chains in solution. |
| title_sort | short peptides assist the folding of free class i heavy chains in solution |
| work_keys_str_mv | AT elliottt shortpeptidesassistthefoldingoffreeclassiheavychainsinsolution AT cerundolov shortpeptidesassistthefoldingoffreeclassiheavychainsinsolution AT townsenda shortpeptidesassistthefoldingoffreeclassiheavychainsinsolution |