Prior experience conditionally inhibits the expression of new learning in Drosophila
Prior experience of a stimulus can inhibit subsequent acquisition or expression of a learned association of that stimulus. However, the neuronal manifestations of this learning effect, named latent inhibition (LI), are poorly understood. Here, we show that prior odor exposure can produce context-dep...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cell Press
2021
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| _version_ | 1826280045346291712 |
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| author | Jacob, PF Vargas-Gutierrez, P Okray, Z Vietti-Michelina, S Felsenberg, J Waddell, S |
| author_facet | Jacob, PF Vargas-Gutierrez, P Okray, Z Vietti-Michelina, S Felsenberg, J Waddell, S |
| author_sort | Jacob, PF |
| collection | OXFORD |
| description | Prior experience of a stimulus can inhibit subsequent acquisition or expression of a learned association of that stimulus. However, the neuronal manifestations of this learning effect, named latent inhibition (LI), are poorly understood. Here, we show that prior odor exposure can produce context-dependent LI of later appetitive olfactory memory performance in Drosophila. Odor pre-exposure forms a short-lived aversive memory whose lone expression lacks context-dependence. Acquisition of odor pre-exposure memory requires aversively reinforcing dopaminergic neurons that innervate two mushroom body compartments—one group of which exhibits increasing activity with successive odor experience. Odor-specific responses of the corresponding mushroom body output neurons are suppressed, and their output is necessary for expression of both pre-exposure memory and LI of appetitive memory. Therefore, odor pre-exposure attaches negative valence to the odor itself, and LI of appetitive memory results from a temporary and context-dependent retrieval deficit imposed by competition with the parallel short-lived aversive memory. |
| first_indexed | 2024-03-07T00:07:49Z |
| format | Journal article |
| id | oxford-uuid:7828b678-0656-48c1-90d7-dc5759850970 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:07:49Z |
| publishDate | 2021 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:7828b678-0656-48c1-90d7-dc57598509702022-03-26T20:28:52ZPrior experience conditionally inhibits the expression of new learning in DrosophilaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7828b678-0656-48c1-90d7-dc5759850970EnglishSymplectic ElementsCell Press2021Jacob, PFVargas-Gutierrez, POkray, ZVietti-Michelina, SFelsenberg, JWaddell, SPrior experience of a stimulus can inhibit subsequent acquisition or expression of a learned association of that stimulus. However, the neuronal manifestations of this learning effect, named latent inhibition (LI), are poorly understood. Here, we show that prior odor exposure can produce context-dependent LI of later appetitive olfactory memory performance in Drosophila. Odor pre-exposure forms a short-lived aversive memory whose lone expression lacks context-dependence. Acquisition of odor pre-exposure memory requires aversively reinforcing dopaminergic neurons that innervate two mushroom body compartments—one group of which exhibits increasing activity with successive odor experience. Odor-specific responses of the corresponding mushroom body output neurons are suppressed, and their output is necessary for expression of both pre-exposure memory and LI of appetitive memory. Therefore, odor pre-exposure attaches negative valence to the odor itself, and LI of appetitive memory results from a temporary and context-dependent retrieval deficit imposed by competition with the parallel short-lived aversive memory. |
| spellingShingle | Jacob, PF Vargas-Gutierrez, P Okray, Z Vietti-Michelina, S Felsenberg, J Waddell, S Prior experience conditionally inhibits the expression of new learning in Drosophila |
| title | Prior experience conditionally inhibits the expression of new learning in Drosophila |
| title_full | Prior experience conditionally inhibits the expression of new learning in Drosophila |
| title_fullStr | Prior experience conditionally inhibits the expression of new learning in Drosophila |
| title_full_unstemmed | Prior experience conditionally inhibits the expression of new learning in Drosophila |
| title_short | Prior experience conditionally inhibits the expression of new learning in Drosophila |
| title_sort | prior experience conditionally inhibits the expression of new learning in drosophila |
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