Implications of the HIV-1 Rev dimer structure at 3.2 A resolution for multimeric binding to the Rev response element.
HIV-1 Rev is a small regulatory protein that mediates the nuclear export of viral mRNAs, an essential step in the HIV replication cycle. In this process Rev oligomerizes in association with a highly structured RNA motif, the Rev response element. Crystallographic studies of Rev have been hampered by...
Главные авторы: | DiMattia, M, Watts, N, Stahl, S, Rader, C, Wingfield, P, Stuart, D, Steven, A, Grimes, J |
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Формат: | Journal article |
Язык: | English |
Опубликовано: |
2010
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