High-resolution comparative mapping of the proximal region of the mouse X chromosome.
The murine homologues of the loci for McLeod syndrome (XK), Dent's disease (CICN5), and synaptophysin (SYP) have been mapped to the proximal region of the mouse X chromosome and positioned with respect to other conserved loci in this region using a total of 948 progeny from two separate Mus mus...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1995
|
| _version_ | 1826280139620614144 |
|---|---|
| author | Blair, H Ho, M Monaco, A Fisher, S Craig, I Boyd, Y |
| author_facet | Blair, H Ho, M Monaco, A Fisher, S Craig, I Boyd, Y |
| author_sort | Blair, H |
| collection | OXFORD |
| description | The murine homologues of the loci for McLeod syndrome (XK), Dent's disease (CICN5), and synaptophysin (SYP) have been mapped to the proximal region of the mouse X chromosome and positioned with respect to other conserved loci in this region using a total of 948 progeny from two separate Mus musculus x Mus spretus backcrosses. In the mouse, the order of loci and evolutionary breakpoints (EB) has been established as centromere-(DXWas70, DXHXF34h)-EB-Clcn5-(Syp, DXMit55, DXMit26)-Tfe3-Gata1-EB-Xk-Cybb-telomere. In the proximal region of the human X chromosome short arm, the position of evolutionary breakpoints with respect to key loci has been established as DMD-EB-XK-PFC-EB-GATA1-C1CN5-EB-DXS1272E-ALAS2-E B-DXF34-centromere. These data have enabled us to construct a high-resolution genetic map for the approximately 3-cM interval between DXWas70 and Cybb on the mouse X chromosome, which encompasses 10 loci. This detailed map demonstrates the power of high-resolution genetic mapping in the mouse as a means of determining locus order in a small chromosomal region and of providing an accurate framework for the construction of physical maps. |
| first_indexed | 2024-03-07T00:09:14Z |
| format | Journal article |
| id | oxford-uuid:78a1220b-9638-4e09-91b8-d0b2133a966a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:09:14Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:78a1220b-9638-4e09-91b8-d0b2133a966a2022-03-26T20:32:01ZHigh-resolution comparative mapping of the proximal region of the mouse X chromosome.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:78a1220b-9638-4e09-91b8-d0b2133a966aEnglishSymplectic Elements at Oxford1995Blair, HHo, MMonaco, AFisher, SCraig, IBoyd, YThe murine homologues of the loci for McLeod syndrome (XK), Dent's disease (CICN5), and synaptophysin (SYP) have been mapped to the proximal region of the mouse X chromosome and positioned with respect to other conserved loci in this region using a total of 948 progeny from two separate Mus musculus x Mus spretus backcrosses. In the mouse, the order of loci and evolutionary breakpoints (EB) has been established as centromere-(DXWas70, DXHXF34h)-EB-Clcn5-(Syp, DXMit55, DXMit26)-Tfe3-Gata1-EB-Xk-Cybb-telomere. In the proximal region of the human X chromosome short arm, the position of evolutionary breakpoints with respect to key loci has been established as DMD-EB-XK-PFC-EB-GATA1-C1CN5-EB-DXS1272E-ALAS2-E B-DXF34-centromere. These data have enabled us to construct a high-resolution genetic map for the approximately 3-cM interval between DXWas70 and Cybb on the mouse X chromosome, which encompasses 10 loci. This detailed map demonstrates the power of high-resolution genetic mapping in the mouse as a means of determining locus order in a small chromosomal region and of providing an accurate framework for the construction of physical maps. |
| spellingShingle | Blair, H Ho, M Monaco, A Fisher, S Craig, I Boyd, Y High-resolution comparative mapping of the proximal region of the mouse X chromosome. |
| title | High-resolution comparative mapping of the proximal region of the mouse X chromosome. |
| title_full | High-resolution comparative mapping of the proximal region of the mouse X chromosome. |
| title_fullStr | High-resolution comparative mapping of the proximal region of the mouse X chromosome. |
| title_full_unstemmed | High-resolution comparative mapping of the proximal region of the mouse X chromosome. |
| title_short | High-resolution comparative mapping of the proximal region of the mouse X chromosome. |
| title_sort | high resolution comparative mapping of the proximal region of the mouse x chromosome |
| work_keys_str_mv | AT blairh highresolutioncomparativemappingoftheproximalregionofthemousexchromosome AT hom highresolutioncomparativemappingoftheproximalregionofthemousexchromosome AT monacoa highresolutioncomparativemappingoftheproximalregionofthemousexchromosome AT fishers highresolutioncomparativemappingoftheproximalregionofthemousexchromosome AT craigi highresolutioncomparativemappingoftheproximalregionofthemousexchromosome AT boydy highresolutioncomparativemappingoftheproximalregionofthemousexchromosome |