A test for the statistical significance of DNA sequence similarities for application in databank searches.
A method is developed, based on word-searching, which provides a rapid test for the statistical significance of DNA sequence similarities for use in databank searching. The method makes allowance for the lengths and dinucleotide compositions of the sequences being compared. A way is also described t...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1989
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| _version_ | 1826280141031997440 |
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| author | Mott, R Kirkwood, T Curnow, R |
| author_facet | Mott, R Kirkwood, T Curnow, R |
| author_sort | Mott, R |
| collection | OXFORD |
| description | A method is developed, based on word-searching, which provides a rapid test for the statistical significance of DNA sequence similarities for use in databank searching. The method makes allowance for the lengths and dinucleotide compositions of the sequences being compared. A way is also described to calculate the power of the test, i.e. the probability of detecting a given similarity as being statistically significant. The effects on the power of the test of the scoring method, word length, sequence length, and sequence composition are examined. A novel scoring method is shown to be superior to the method currently used in most word-searching algorithms. |
| first_indexed | 2024-03-07T00:09:15Z |
| format | Journal article |
| id | oxford-uuid:78a25f65-545d-425b-841d-620f3d1c6bb0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:09:15Z |
| publishDate | 1989 |
| record_format | dspace |
| spelling | oxford-uuid:78a25f65-545d-425b-841d-620f3d1c6bb02022-03-26T20:32:01ZA test for the statistical significance of DNA sequence similarities for application in databank searches.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:78a25f65-545d-425b-841d-620f3d1c6bb0EnglishSymplectic Elements at Oxford1989Mott, RKirkwood, TCurnow, RA method is developed, based on word-searching, which provides a rapid test for the statistical significance of DNA sequence similarities for use in databank searching. The method makes allowance for the lengths and dinucleotide compositions of the sequences being compared. A way is also described to calculate the power of the test, i.e. the probability of detecting a given similarity as being statistically significant. The effects on the power of the test of the scoring method, word length, sequence length, and sequence composition are examined. A novel scoring method is shown to be superior to the method currently used in most word-searching algorithms. |
| spellingShingle | Mott, R Kirkwood, T Curnow, R A test for the statistical significance of DNA sequence similarities for application in databank searches. |
| title | A test for the statistical significance of DNA sequence similarities for application in databank searches. |
| title_full | A test for the statistical significance of DNA sequence similarities for application in databank searches. |
| title_fullStr | A test for the statistical significance of DNA sequence similarities for application in databank searches. |
| title_full_unstemmed | A test for the statistical significance of DNA sequence similarities for application in databank searches. |
| title_short | A test for the statistical significance of DNA sequence similarities for application in databank searches. |
| title_sort | test for the statistical significance of dna sequence similarities for application in databank searches |
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