Exon structure of the collagen-binding domain of human fibronectin.
Fibronectin consists of a series of three internal homology repeats (types I, II, and III [(1983) Proc. Natl. Acad. Sci. USA 80, 137-141]). The type III units are each coded for by two exons with the exception of the alternatively spliced extra domain type III [(1984) EMBO J. 3, 2511-2516]. To inves...
| Үндсэн зохиолчид: | , |
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| Формат: | Journal article |
| Хэл сонгох: | English |
| Хэвлэсэн: |
1986
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| _version_ | 1826280189375545344 |
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| author | Owens, R Baralle, F |
| author_facet | Owens, R Baralle, F |
| author_sort | Owens, R |
| collection | OXFORD |
| description | Fibronectin consists of a series of three internal homology repeats (types I, II, and III [(1983) Proc. Natl. Acad. Sci. USA 80, 137-141]). The type III units are each coded for by two exons with the exception of the alternatively spliced extra domain type III [(1984) EMBO J. 3, 2511-2516]. To investigate the gene organisation of the type I and II repeats, genomic clones covering the collagen-binding domain of human fibronectin have been isolated and characterised. The results show that each of the type I and II homology units in this region corresponds to an exon. Taken together with the previous data concerning the type III units, the data lend support to a gene fusion model of fibronectin evolution. |
| first_indexed | 2024-03-07T00:09:58Z |
| format | Journal article |
| id | oxford-uuid:78e5de70-7aad-43f5-b549-94f9ad17807e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:09:58Z |
| publishDate | 1986 |
| record_format | dspace |
| spelling | oxford-uuid:78e5de70-7aad-43f5-b549-94f9ad17807e2022-03-26T20:33:41ZExon structure of the collagen-binding domain of human fibronectin.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:78e5de70-7aad-43f5-b549-94f9ad17807eEnglishSymplectic Elements at Oxford1986Owens, RBaralle, FFibronectin consists of a series of three internal homology repeats (types I, II, and III [(1983) Proc. Natl. Acad. Sci. USA 80, 137-141]). The type III units are each coded for by two exons with the exception of the alternatively spliced extra domain type III [(1984) EMBO J. 3, 2511-2516]. To investigate the gene organisation of the type I and II repeats, genomic clones covering the collagen-binding domain of human fibronectin have been isolated and characterised. The results show that each of the type I and II homology units in this region corresponds to an exon. Taken together with the previous data concerning the type III units, the data lend support to a gene fusion model of fibronectin evolution. |
| spellingShingle | Owens, R Baralle, F Exon structure of the collagen-binding domain of human fibronectin. |
| title | Exon structure of the collagen-binding domain of human fibronectin. |
| title_full | Exon structure of the collagen-binding domain of human fibronectin. |
| title_fullStr | Exon structure of the collagen-binding domain of human fibronectin. |
| title_full_unstemmed | Exon structure of the collagen-binding domain of human fibronectin. |
| title_short | Exon structure of the collagen-binding domain of human fibronectin. |
| title_sort | exon structure of the collagen binding domain of human fibronectin |
| work_keys_str_mv | AT owensr exonstructureofthecollagenbindingdomainofhumanfibronectin AT barallef exonstructureofthecollagenbindingdomainofhumanfibronectin |