Severe polyposis in Apc1322T mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5

Severe polyposis in Apc1322T mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5

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Background and aims: Adenomatous polyposis coli (APC) is a tumour suppressor gene mutated in the germline of patients with familial adenomatous polyposis (FAP) and somatically in most colorectal cancers. APC mutations impair β-catenin degradation, resulting in increased Wnt signalling. The most freq...

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Bibliographic Details
Main Authors:	Lewis, A, Segditsas, S, Deheragoda, M, Pollard, P, Jeffery, R, Nye, E, Lockstone, H, Davis, H, Clark, S, Stamp, G, Poulsom, R, Wright, N, Tomlinson, I
Format:	Journal article
Language:	English
Published:	2010

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