Ex vivo T-cell depletion with the monoclonal antibody Campath-1 plus human complement effectively prevents acute graft-versus-host disease in allogeneic bone marrow transplantation.
We have developed a rapid and simple procedure for the elimination of mature T-cells from the donor marrow using a single incubation with the monoclonal antibody Campath-1 and donor complement. This resulted in a reduction of T-cell contamination to a mean of 1%. This regimen reduced the incidence o...
| Päätekijät: | , , , , , , , |
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| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
1986
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| _version_ | 1826280217843335168 |
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| author | Heit, W Bunjes, D Wiesneth, M Schmeiser, T Arnold, R Hale, G Waldmann, H Heimpel, H |
| author_facet | Heit, W Bunjes, D Wiesneth, M Schmeiser, T Arnold, R Hale, G Waldmann, H Heimpel, H |
| author_sort | Heit, W |
| collection | OXFORD |
| description | We have developed a rapid and simple procedure for the elimination of mature T-cells from the donor marrow using a single incubation with the monoclonal antibody Campath-1 and donor complement. This resulted in a reduction of T-cell contamination to a mean of 1%. This regimen reduced the incidence of acute graft-versus-host disease significantly in 21 consecutive bone marrow grafts in 18 patients with leukaemia and non-Hodgkin's lymphoma. Purging was responsible for an increased incidence of graft rejection in HLA-identical transplants (13%). |
| first_indexed | 2024-03-07T00:10:24Z |
| format | Journal article |
| id | oxford-uuid:7907351c-d7dd-41eb-9954-b725110be2e1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:10:24Z |
| publishDate | 1986 |
| record_format | dspace |
| spelling | oxford-uuid:7907351c-d7dd-41eb-9954-b725110be2e12022-03-26T20:34:43ZEx vivo T-cell depletion with the monoclonal antibody Campath-1 plus human complement effectively prevents acute graft-versus-host disease in allogeneic bone marrow transplantation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7907351c-d7dd-41eb-9954-b725110be2e1EnglishSymplectic Elements at Oxford1986Heit, WBunjes, DWiesneth, MSchmeiser, TArnold, RHale, GWaldmann, HHeimpel, HWe have developed a rapid and simple procedure for the elimination of mature T-cells from the donor marrow using a single incubation with the monoclonal antibody Campath-1 and donor complement. This resulted in a reduction of T-cell contamination to a mean of 1%. This regimen reduced the incidence of acute graft-versus-host disease significantly in 21 consecutive bone marrow grafts in 18 patients with leukaemia and non-Hodgkin's lymphoma. Purging was responsible for an increased incidence of graft rejection in HLA-identical transplants (13%). |
| spellingShingle | Heit, W Bunjes, D Wiesneth, M Schmeiser, T Arnold, R Hale, G Waldmann, H Heimpel, H Ex vivo T-cell depletion with the monoclonal antibody Campath-1 plus human complement effectively prevents acute graft-versus-host disease in allogeneic bone marrow transplantation. |
| title | Ex vivo T-cell depletion with the monoclonal antibody Campath-1 plus human complement effectively prevents acute graft-versus-host disease in allogeneic bone marrow transplantation. |
| title_full | Ex vivo T-cell depletion with the monoclonal antibody Campath-1 plus human complement effectively prevents acute graft-versus-host disease in allogeneic bone marrow transplantation. |
| title_fullStr | Ex vivo T-cell depletion with the monoclonal antibody Campath-1 plus human complement effectively prevents acute graft-versus-host disease in allogeneic bone marrow transplantation. |
| title_full_unstemmed | Ex vivo T-cell depletion with the monoclonal antibody Campath-1 plus human complement effectively prevents acute graft-versus-host disease in allogeneic bone marrow transplantation. |
| title_short | Ex vivo T-cell depletion with the monoclonal antibody Campath-1 plus human complement effectively prevents acute graft-versus-host disease in allogeneic bone marrow transplantation. |
| title_sort | ex vivo t cell depletion with the monoclonal antibody campath 1 plus human complement effectively prevents acute graft versus host disease in allogeneic bone marrow transplantation |
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