B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.

B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.

Druggable proteins required for B lymphocyte survival and immune responses are an emerging source of new treatments for autoimmunity and lymphoid malignancy. In this study, we show that mice with an inactivating mutation in the intramembrane protease signal peptide peptidase-like 2A (SPPL2A) unexpec...

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Bibliographic Details
Main Authors: Bergmann, H, Yabas, M, Short, A, Miosge, L, Barthel, N, Teh, C, Roots, C, Bull, K, Jeelall, Y, Horikawa, K, Whittle, B, Balakishnan, B, Sjollema, G, Bertram, E, Mackay, F, Rimmer, A, Cornall, R, Field, M, Andrews, T, Goodnow, C, Enders, A
Format: Journal article
Language:English
Published: 2013

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