MEDI 73-Modeling, synthetic, crystallographic, and activity studies of novel bisphosphonates as inhibitors of farnesyl pyrophosphate synthase

Podrobná bibliografie
Hlavní autoři:	Hogan, J, Deprele, S, Kashemirov, B, Barnett, B, Evdokimov, A, Dunford, J, Russell, R, Ebetino, F, McKenna, C
Médium:	Journal article
Vydáno:	2007

A mirror image pair of bisphosphonate analogs further demonstrates the mode of binding of the bisphosphonates in farnesyl pyrophosphate synthase
Autor: Ebetino, F, a další
Vydáno: (2008)

The mode of binding of nitrogen containing bisphosphonates in farnesyl pyrophosphate synthase
Autor: Ebetino, F, a další
Vydáno: (2007)

The Role of Active Site Threonine 201 in the Inhibition of Farnesyl Pyrophosphate Synthase by Nitrogen Containing Bisphosphonates
Autor: Dunford, J, a další
Vydáno: (2008)

Evidence for the involvement of the threonine 201 side-chain in the interaction of nitrogen-containing bisphosphonates with farnesyl pyrophosphate synthase
Autor: Kwassi, A, a další
Vydáno: (2009)

Analysis of the kinetic mechanism of inhibition of Farnesyl Pyrophosphate Synthase by nitrogen containing bisphosphonates.
Autor: Dunford, J, a další
Vydáno: (2006)

Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates
Autor: Dunford, J, a další
Vydáno: (2007)

The interaction of sidechain nitrogen with active site threonine is not essential for inhibition of farnesyl pyrophosphate synthase by nitrogen containing bisphosphonates
Autor: Dunford, J, a další
Vydáno: (2008)

Molecular interactions of nitrogen-containing bisphosphonates within farnesyl diphosphate synthase
Autor: Ebetino, F, a další
Vydáno: (2005)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
Autor: Ebetino, F, a další
Vydáno: (2006)

Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonates
Autor: Evdokimov, A, a další
Vydáno: (2006)

Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase
Autor: Dunford, J, a další
Vydáno: (2008)

Interaction of the active site threonine 201 sidechain with the nitrogen of nttrogen-containing bisphosphonates is not essential for slow tight inhibition to farnesyl pyrophosphate synthase
Autor: Dunford, J, a další
Vydáno: (2008)

Modeling of bisphosphonate binding to farnesyl diphosphate synthase
Autor: Ebetino, F, a další
Vydáno: (2002)

Refining structure activity relationships among nitrogen containing bisphosphonates: Dissociation of mineral binding affinity and inhibitory potency on farnesyl diphosphate synthase.
Autor: Xia, Z, a další
Vydáno: (2006)

Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates
Autor: Dunford, J, a další
Vydáno: (2007)

Stereochemical evidence of the mode of binding of nitrogen containing bisphosphonates in farnesyl diphosphate synthase
Autor: Ebetino, F, a další
Vydáno: (2007)

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.
Autor: Dunford, J, a další
Vydáno: (2008)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
Autor: Ebetino, F, a další
Vydáno: (2006)

Nitrogen-containing bisphosphonates of varying antiresorptive potency have been co-crystallized in farnesyl diphosphate synthase and modelled to understand the key structural features involved in enzyme inhibition.
Autor: Ebetino, F, a další
Vydáno: (2006)

Predicting the clinical potencies of bisphosphonates: Divergence of hydroxyapatite and farnesyl diphosphate synthase binding affinities
Autor: Xia, Z, a další
Vydáno: (2007)

Designed mutants of human farnesyl pyrophosphate synthase (FPPS) help to characterise the interactions of nitrogen-containing bisphosphonates with Tyrosine 204 and Phenylalanine 239 side-chain residues
Autor: Tsoumpra, M, a další
Vydáno: (2010)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.
Autor: Tsoumpra, M, a další
Vydáno: (2015)

Bisphosphonate affinity to hydroxyapatite and farnesyl pyrophosphate inhibitory potency, together, drive in vivo efficacy
Autor: Lundy, M, a další
Vydáno: (2007)

Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates
Autor: Dunford, J, a další
Vydáno: (2006)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants
Autor: Tsoumpra, MK, a další
Vydáno: (2015)

Molecular modeling of the bisphosphonates (BPs) in farnesyl diphosphate (FPP) synthase. Proposed new mechanism of inhibition by potent nitrogen containing bisphosphonates (NBPs).
Autor: Ebetino, F, a další
Vydáno: (2002)

Molecular modeling of the bisphosphonates in farnesyl diphosphate synthase. potential new details of the precise biochemical mechanism of action of potent nitrogen containing bisphosphonates
Autor: Ebetino, F, a další
Vydáno: (2002)

Human farnesyl diphosphate synthase (FDFS): Crystal structure and molecular interactions with Nnitrogen-containing bisphosphonates.
Autor: Kavanagh, K, a další
Vydáno: (2005)

New anti-candida active nitrogen-containing bisphosphonates as inhibitors of farnesyl pyrophosphate synthase Candida albicans
Autor: L. O. Metelytsia, a další
Vydáno: (2019-05-01)

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells
Autor: Räikkönen, J, a další
Vydáno: (2011)

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells.
Autor: Räikkönen, J, a další
Vydáno: (2011)

Inhibition of human mevalonate kinase by allosteric inhibitors of farnesyl pyrophosphate synthase
Autor: Saman Salari, a další
Vydáno: (2024-08-01)

Molecular Cloning and Characterisation of Farnesyl Pyrophosphate Synthase from Tripterygium wilfordii.
Autor: Yu-Jun Zhao, a další
Vydáno: (2015-01-01)

Functional characterization of the Xanthophyllomyces dendrorhous farnesyl pyrophosphate synthase and geranylgeranyl pyrophosphate synthase encoding genes that are involved in the synthesis of isoprenoid precursors.
Autor: Jennifer Alcaíno, a další
Vydáno: (2014-01-01)

The relationship between the chemistry and biological activity of the bisphosphonates.
Autor: Ebetino, F, a další
Vydáno: (2011)

Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase
Autor: Kavanagh, K, a další
Vydáno: (2006)

Role of the geminal hydroxyl group in target enzyme inhibition by bisphosphonates and phosphonocarboxylates
Autor: Stewart, C, a další
Vydáno: (2007)

Differential effects of alpha-halogenation on the potency of bisphosphonates and phosphonocarboxylates for inhibition of their target enzymes
Autor: Stewart, C, a další
Vydáno: (2007)

Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate.
Autor: Marma, MS, a další
Vydáno: (2007)

Nitrogen-containing bisphosphonate induces enhancement of OPG expression and inhibition of RANKL expression via inhibition of farnesyl pyrophosphate synthase to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells
Autor: Wei Xu, a další
Vydáno: (2024-09-01)

MEDI 73-Modeling, synthetic, crystallographic, and activity studies of novel bisphosphonates as inhibitors of farnesyl pyrophosphate synthase

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