Long-term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancer
Liver metastasis from breast cancer is associated with poor prognosis and is a major cause of early morbidity and mortality. When liver resection is not feasible, minimally invasive directed therapies are considered to attempt to prolong survival. Selective internal radiation therapy (SIRT) with ytt...
| Автори: | , , , , , , , , , , , |
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| Формат: | Journal article |
| Мова: | English |
| Опубліковано: |
Elsevier
2018
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| _version_ | 1826280264630796288 |
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| author | Lyon, P Winter, H Herbschleb, K Campo, L Carlisle, R Wu, F Goldin, R Coussios, C Middleton, M Gleeson, F Boardman, P Sharma, R |
| author_facet | Lyon, P Winter, H Herbschleb, K Campo, L Carlisle, R Wu, F Goldin, R Coussios, C Middleton, M Gleeson, F Boardman, P Sharma, R |
| author_sort | Lyon, P |
| collection | OXFORD |
| description | Liver metastasis from breast cancer is associated with poor prognosis and is a major cause of early morbidity and mortality. When liver resection is not feasible, minimally invasive directed therapies are considered to attempt to prolong survival. Selective internal radiation therapy (SIRT) with yttrium-90 microspheres is a liver-directed therapy that can improve local control of liver metastases from colorectal cancer. We present a case of a patient with a ductal breast adenocarcinoma, who developed liver and bone metastasis despite extensive treatment with systemic chemotherapies. Following SIRT to the liver, after an initial response, the patient ultimately progressed in the liver after 7 months. Liver tumor histology obtained 20 months after the SIRT intervention demonstrated the presence of the resin microspheres in situ. This case report demonstrates the long-term control that may be achieved with SIRT to treat liver metastases from breast cancer that is refractory to previous chemotherapies, and the presence of microspheres in situ long-term. |
| first_indexed | 2024-03-07T00:11:06Z |
| format | Journal article |
| id | oxford-uuid:7941936b-b94a-421b-9339-8ae43ae6323b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:11:06Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:7941936b-b94a-421b-9339-8ae43ae6323b2022-03-26T20:36:18ZLong-term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancerJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7941936b-b94a-421b-9339-8ae43ae6323bEnglishSymplectic Elements at OxfordElsevier2018Lyon, PWinter, HHerbschleb, KCampo, LCarlisle, RWu, FGoldin, RCoussios, CMiddleton, MGleeson, FBoardman, PSharma, RLiver metastasis from breast cancer is associated with poor prognosis and is a major cause of early morbidity and mortality. When liver resection is not feasible, minimally invasive directed therapies are considered to attempt to prolong survival. Selective internal radiation therapy (SIRT) with yttrium-90 microspheres is a liver-directed therapy that can improve local control of liver metastases from colorectal cancer. We present a case of a patient with a ductal breast adenocarcinoma, who developed liver and bone metastasis despite extensive treatment with systemic chemotherapies. Following SIRT to the liver, after an initial response, the patient ultimately progressed in the liver after 7 months. Liver tumor histology obtained 20 months after the SIRT intervention demonstrated the presence of the resin microspheres in situ. This case report demonstrates the long-term control that may be achieved with SIRT to treat liver metastases from breast cancer that is refractory to previous chemotherapies, and the presence of microspheres in situ long-term. |
| spellingShingle | Lyon, P Winter, H Herbschleb, K Campo, L Carlisle, R Wu, F Goldin, R Coussios, C Middleton, M Gleeson, F Boardman, P Sharma, R Long-term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancer |
| title | Long-term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancer |
| title_full | Long-term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancer |
| title_fullStr | Long-term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancer |
| title_full_unstemmed | Long-term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancer |
| title_short | Long-term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancer |
| title_sort | long term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancer |
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