The molecular dissection of TRIM25’s RNA-binding mechanism provides key insights into its antiviral activity

The molecular dissection of TRIM25’s RNA-binding mechanism provides key insights into its antiviral activity

TRIM25 is an RNA-binding ubiquitin E3 ligase with central but poorly understood roles in the innate immune response to RNA viruses. The link between TRIM25’s RNA binding and its role in innate immunity has not been established. Thus, we utilized a multitude of biophysical techniques to identify key...

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Bibliografiske detaljer
Main Authors: Álvarez, L, Haubrich, K, Iselin, L, Gillioz, L, Ruscica, V, Lapouge, K, Augsten, S, Huppertz, I, Choudhury, NR, Simon, B, Masiewicz, P, Lethier, M, Cusack, S, Rittinger, K, Gabel, F, Leitner, A, Michlewski, G, Hentze, MW, Allain, FHT, Castello, A, Hennig, J
Format: Journal article
Sprog:English
Udgivet: Nature Research 2024

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