Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?

Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?

Show other versions (1)

Multiple sclerosis afflicts more than 1 million individuals worldwide and is widely considered to be an autoimmune disease. Traditionally, CD4(+) T helper cells have almost exclusively been held responsible for its immunopathogenesis, partly because certain MHC class II alleles clearly predispose fo...

Full description

Bibliographic Details
Main Authors:	Friese, M, Fugger, L
Format:	Journal article
Language:	English
Published:	2005

Similar Items

Autoreactive CD8+ T cells in multiple sclerosis: A new target for therapy?
by: Friese, M, et al.
Published: (2005)

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis.
by: Friese, M, et al.
Published: (2008)

Pathogenic CD8(+) T cells in multiple sclerosis.
by: Friese, M, et al.
Published: (2009)

Autoreactive lymphocytes in multiple sclerosis: Pathogenesis and treatment target
by: Rongzeng Liu, et al.
Published: (2022-09-01)

T cells and microglia as drivers of multiple sclerosis pathology
by: Friese, M, et al.
Published: (2007)

T cells and microglia as drivers of multiple sclerosis pathology.
by: Friese, M, et al.
Published: (2007)

Joint-specific and systemic autoreactivity in the development of inflammatory arthritis.
by: Fugger, L
Published: (2000)

Humanized Mice Reveal New Insights Into the Thymic Selection of Human Autoreactive CD8+ T Cells
by: Yang Li, et al.
Published: (2019-02-01)

New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes
by: Christine Bender, et al.
Published: (2021-01-01)

The immunology of multiple sclerosis
by: Attfield, KE, et al.
Published: (2022)

From genes to function: the next challenge to understanding multiple sclerosis
by: Fugger, L, et al.
Published: (2009)

From genes to function: the next challenge to understanding multiple sclerosis.
by: Fugger, L, et al.
Published: (2009)

Immunological tolerance to muscle autoantigens involves peripheral deletion of autoreactive CD8+ T cells.
by: Emilie Franck, et al.
Published: (2012-01-01)

Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8+ T cells
by: Leeana D. Peters, et al.
Published: (2023-05-01)

Sustained effects on immune cell subsets and autoreactivity in multiple sclerosis patients treated with oral cladribine
by: Rikke Holm Hansen, et al.
Published: (2024-02-01)

Interleukin-17 expression in multiple sclerosis
by: Tzartos, J, et al.
Published: (2006)

INVOLVEMENT OF CD8+ T CELLS IN MULTIPLE SCLEROSIS
by: Marion eSalou, et al.
Published: (2015-11-01)

Human autoreactive T cells recognize CD1b and phospholipids.
by: Van Rhijn, I, et al.
Published: (2016)

Multiple sclerosis: MHC associations and therapeutic implications.
by: Holmes, S, et al.
Published: (2005)

Misfiring in multiple sclerosis: cerebellar channelopathy, a potential novel target?
by: Craner, M, et al.
Published: (2012)

New insights into developmental fate decisions by autoreactive CD4 thymocytes
by: Xuguang Tai, et al.
Published: (2024-02-01)

CD8+ T cells as immune regulators of multiple sclerosis
by: Sushmita eSinha, et al.
Published: (2015-12-01)

Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis
by: Kaufmann, M, et al.
Published: (2021)

The value of animal models for drug development in multiple sclerosis.
by: Friese, M, et al.
Published: (2006)

The value of animal models for drug development in multiple sclerosis
by: Friese, M, et al.
Published: (2006)

Identifying Patient-Specific Epstein-Barr Nuclear Antigen-1 Genetic Variation and Potential Autoreactive Targets Relevant to Multiple Sclerosis Pathogenesis.
by: Monika Tschochner, et al.
Published: (2016-01-01)

Atypical sideways recognition of CD1a by autoreactive γδ T cell receptors
by: Marcin Wegrecki, et al.
Published: (2022-07-01)

Therapeutic Targeting of Autoreactive B Cells: Why, How, and When?
by: Zachary C. Stensland, et al.
Published: (2021-01-01)

Communication of CD8+ T cells with mononuclear phagocytes in multiple sclerosis
by: Matea Konjevic Sabolek, et al.
Published: (2019-07-01)

Chronic chagasic cardiopathy: role of CD4 T cells in the anti heart autoreactivity
by: Ricardo Ribeiro dos Santos, et al.
Published: (1990-09-01)

TYK2 signaling promotes the development of autoreactive CD8+ cytotoxic T lymphocytes and type 1 diabetes
by: Keiichiro Mine, et al.
Published: (2024-02-01)

Direct modulation of myelin-autoreactive CD4+ and CD8+ T cells in EAE mice by a tolerogenic nanoparticle co-carrying myelin peptide-loaded major histocompatibility complexes, CD47 and multiple regulatory molecules
by: Pei W, et al.
Published: (2018-06-01)

Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients
by: Rivas, JR, et al.
Published: (2016)

Therapies for multiple sclerosis: translational achievements and outstanding needs.
by: Haghikia, A, et al.
Published: (2013)

Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.
by: Tzartos, J, et al.
Published: (2008)

Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies.
by: Takeo Kuwata, et al.
Published: (2009-04-01)

Group A streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation
by: Chen, Y-L, et al.
Published: (2023)

Depletion of CD25+ regulatory cells results in suppression of melanomagrowth and induction of autoreactivity in mice
by: Jones, E, et al.
Published: (2002)

Autoreactive effector/memory CD4+ and CD8+ T cells infiltrating grafted and endogenous islets in diabetic NOD mice exhibit similar T cell receptor usage.
by: Ramiro Diz, et al.
Published: (2012-01-01)

Pathogenic CD8 T cells in Multiple Sclerosis and its experimental models
by: Eric S. Huseby, et al.
Published: (2012-03-01)