Systematic review protocol: an assessment of the post-approval challenges of autologous CAR-T therapy delivery
Following recent regulatory approvals of two chimeric antigen receptor T-cell (CAR-T) therapies, the field now faces a number of post-approval challenges. These challenges are in some respects defined and, in others, uncertain due to the nascence of the field. At present, information pertaining to s...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
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BMJ Journals
2019
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| _version_ | 1797077045311700992 |
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| author | Lam, C Meinert, E Halioua-Haubold, C Carter, A Yang, A Brindley, D Cui, Z |
| author_facet | Lam, C Meinert, E Halioua-Haubold, C Carter, A Yang, A Brindley, D Cui, Z |
| author_sort | Lam, C |
| collection | OXFORD |
| description | Following recent regulatory approvals of two chimeric antigen receptor T-cell (CAR-T) therapies, the field now faces a number of post-approval challenges. These challenges are in some respects defined and, in others, uncertain due to the nascence of the field. At present, information pertaining to such post-approval challenges are scattered in various previous reviews or raised in singular papers reporting experience in working with the therapy. This systematic review is designed to evaluate and summarise the post-approval challenges for robust delivery of CAR-T therapies to inform future work on the optimisation of CAR-T delivery to patients. |
| first_indexed | 2024-03-07T00:12:10Z |
| format | Journal article |
| id | oxford-uuid:799bfee3-b74e-4a15-9ab8-5479fe12850c |
| institution | University of Oxford |
| last_indexed | 2024-03-07T00:12:10Z |
| publishDate | 2019 |
| publisher | BMJ Journals |
| record_format | dspace |
| spelling | oxford-uuid:799bfee3-b74e-4a15-9ab8-5479fe12850c2022-03-26T20:38:33ZSystematic review protocol: an assessment of the post-approval challenges of autologous CAR-T therapy deliveryJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:799bfee3-b74e-4a15-9ab8-5479fe12850cSymplectic Elements at OxfordBMJ Journals2019Lam, CMeinert, EHalioua-Haubold, CCarter, AYang, ABrindley, DCui, ZFollowing recent regulatory approvals of two chimeric antigen receptor T-cell (CAR-T) therapies, the field now faces a number of post-approval challenges. These challenges are in some respects defined and, in others, uncertain due to the nascence of the field. At present, information pertaining to such post-approval challenges are scattered in various previous reviews or raised in singular papers reporting experience in working with the therapy. This systematic review is designed to evaluate and summarise the post-approval challenges for robust delivery of CAR-T therapies to inform future work on the optimisation of CAR-T delivery to patients. |
| spellingShingle | Lam, C Meinert, E Halioua-Haubold, C Carter, A Yang, A Brindley, D Cui, Z Systematic review protocol: an assessment of the post-approval challenges of autologous CAR-T therapy delivery |
| title | Systematic review protocol: an assessment of the post-approval challenges of autologous CAR-T therapy delivery |
| title_full | Systematic review protocol: an assessment of the post-approval challenges of autologous CAR-T therapy delivery |
| title_fullStr | Systematic review protocol: an assessment of the post-approval challenges of autologous CAR-T therapy delivery |
| title_full_unstemmed | Systematic review protocol: an assessment of the post-approval challenges of autologous CAR-T therapy delivery |
| title_short | Systematic review protocol: an assessment of the post-approval challenges of autologous CAR-T therapy delivery |
| title_sort | systematic review protocol an assessment of the post approval challenges of autologous car t therapy delivery |
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