Structural basis for the interaction of lactivicins with serine beta-lactamases.

Lactivicin (LTV) is a natural non-beta-lactam antibiotic that inhibits penicillin-binding proteins and serine beta-lactamases. A crystal structure of a BS3-LTV complex reveals that, as for its reaction with PBPs, LTV reacts with the nucleophilic serine and that cycloserine and lactone rings of LTV a...

詳細記述

書誌詳細
主要な著者: Brown, T, Charlier, P, Herman, R, Schofield, C, Sauvage, E
フォーマット: Journal article
言語:English
出版事項: 2010