Can the cardiomyocyte cell cycle be reprogrammed?
Cardiac repair following myocardial injury is restricted due to the limited proliferative potential of adult cardiomyocytes. The ability of mammalian cardiomyocytes to proliferate is lost shortly after birth as cardiomyocytes withdraw from the cell cycle and differentiate. We do not fully understand...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1797077075922780160 |
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| author | Bicknell, K Coxon, C Brooks, G |
| author_facet | Bicknell, K Coxon, C Brooks, G |
| author_sort | Bicknell, K |
| collection | OXFORD |
| description | Cardiac repair following myocardial injury is restricted due to the limited proliferative potential of adult cardiomyocytes. The ability of mammalian cardiomyocytes to proliferate is lost shortly after birth as cardiomyocytes withdraw from the cell cycle and differentiate. We do not fully understand the molecular and cellular mechanisms that regulate this cell cycle withdrawal, although if we could it might lead to the discovery of novel therapeutic targets for improving cardiac repair following myocardial injury. For the last decade, researchers have investigated cardiomyocyte cell cycle control, commonly using transgenic mouse models or recombinant adenoviruses to manipulate cell cycle regulators in vivo or in vitro. This review discusses cardiomyocyte cell cycle regulation and summarises recent data from studies manipulating the expressions and activities of cell cycle regulators in cardiomyocytes. The validity of therapeutic strategies that aim to reinstate the proliferative potential of cardiomyocytes to improve myocardial repair following injury will be discussed. |
| first_indexed | 2024-03-07T00:12:38Z |
| format | Journal article |
| id | oxford-uuid:79c17f37-e3ea-4e25-b3fd-e5def6a08631 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:12:38Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:79c17f37-e3ea-4e25-b3fd-e5def6a086312022-03-26T20:39:25ZCan the cardiomyocyte cell cycle be reprogrammed?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:79c17f37-e3ea-4e25-b3fd-e5def6a08631EnglishSymplectic Elements at Oxford2007Bicknell, KCoxon, CBrooks, GCardiac repair following myocardial injury is restricted due to the limited proliferative potential of adult cardiomyocytes. The ability of mammalian cardiomyocytes to proliferate is lost shortly after birth as cardiomyocytes withdraw from the cell cycle and differentiate. We do not fully understand the molecular and cellular mechanisms that regulate this cell cycle withdrawal, although if we could it might lead to the discovery of novel therapeutic targets for improving cardiac repair following myocardial injury. For the last decade, researchers have investigated cardiomyocyte cell cycle control, commonly using transgenic mouse models or recombinant adenoviruses to manipulate cell cycle regulators in vivo or in vitro. This review discusses cardiomyocyte cell cycle regulation and summarises recent data from studies manipulating the expressions and activities of cell cycle regulators in cardiomyocytes. The validity of therapeutic strategies that aim to reinstate the proliferative potential of cardiomyocytes to improve myocardial repair following injury will be discussed. |
| spellingShingle | Bicknell, K Coxon, C Brooks, G Can the cardiomyocyte cell cycle be reprogrammed? |
| title | Can the cardiomyocyte cell cycle be reprogrammed? |
| title_full | Can the cardiomyocyte cell cycle be reprogrammed? |
| title_fullStr | Can the cardiomyocyte cell cycle be reprogrammed? |
| title_full_unstemmed | Can the cardiomyocyte cell cycle be reprogrammed? |
| title_short | Can the cardiomyocyte cell cycle be reprogrammed? |
| title_sort | can the cardiomyocyte cell cycle be reprogrammed |
| work_keys_str_mv | AT bicknellk canthecardiomyocytecellcyclebereprogrammed AT coxonc canthecardiomyocytecellcyclebereprogrammed AT brooksg canthecardiomyocytecellcyclebereprogrammed |