Beta oscillation-targeted neurofeedback training based on subthalamic LFPs in Parkinsonian patients
Increased oscillatory activities in the beta frequency band (13-30 Hz) in the subthalamic nucleus (STN), and in particular prolonged episodes of increased synchrony in this frequency band, have been associated with motor symptoms such as bradykinesia and rigidity in Parkinson's disease (PD). Nu...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Conference item |
| Published: |
Institute of Electrical and Electronics Engineers
2019
|
| _version_ | 1826280384571113472 |
|---|---|
| author | He, S Syed, E Torrecillos, F Tinkhauser, G Fischer, P Pogosyan, A Pereira, E Ashkan, K Hasegawa, H Brown, P Tan, H |
| author_facet | He, S Syed, E Torrecillos, F Tinkhauser, G Fischer, P Pogosyan, A Pereira, E Ashkan, K Hasegawa, H Brown, P Tan, H |
| author_sort | He, S |
| collection | OXFORD |
| description | Increased oscillatory activities in the beta frequency band (13-30 Hz) in the subthalamic nucleus (STN), and in particular prolonged episodes of increased synchrony in this frequency band, have been associated with motor symptoms such as bradykinesia and rigidity in Parkinson's disease (PD). Numerous studies have investigated sensorimotor cortical beta oscillations either as a control signal for Brain Computer Interfaces (BCI) or as target signal for neurofeedback training (NFB). However, it still remains unknown whether patients with PD can gain control of the pathological oscillations recorded from a subcortical site - the STN - with neurofeedback training. We tried to address this question in the current study. Specifically, we designed a simple basketball game, in which the position of a basketball changes based on the occurrence of events of temporally increased beta power quantified in real-time. Participants practised in the game to control the position of the basketball, which requires modulation of the beta oscillations recorded from STN local field potentials (LFPs). Our results suggest that it is possible to use neurofeedback training for PD patients to downregulate pathological beta oscillations in STN LFPs, and that this can lead to a reduction of beta oscillations in the cortical-STN motor network. |
| first_indexed | 2024-03-07T00:12:54Z |
| format | Conference item |
| id | oxford-uuid:79d87542-bc2b-4782-a5c0-0336c11b66cc |
| institution | University of Oxford |
| last_indexed | 2024-03-07T00:12:54Z |
| publishDate | 2019 |
| publisher | Institute of Electrical and Electronics Engineers |
| record_format | dspace |
| spelling | oxford-uuid:79d87542-bc2b-4782-a5c0-0336c11b66cc2022-03-26T20:40:02ZBeta oscillation-targeted neurofeedback training based on subthalamic LFPs in Parkinsonian patientsConference itemhttp://purl.org/coar/resource_type/c_5794uuid:79d87542-bc2b-4782-a5c0-0336c11b66ccSymplectic Elements at OxfordInstitute of Electrical and Electronics Engineers2019He, SSyed, ETorrecillos, FTinkhauser, GFischer, PPogosyan, APereira, EAshkan, KHasegawa, HBrown, PTan, HIncreased oscillatory activities in the beta frequency band (13-30 Hz) in the subthalamic nucleus (STN), and in particular prolonged episodes of increased synchrony in this frequency band, have been associated with motor symptoms such as bradykinesia and rigidity in Parkinson's disease (PD). Numerous studies have investigated sensorimotor cortical beta oscillations either as a control signal for Brain Computer Interfaces (BCI) or as target signal for neurofeedback training (NFB). However, it still remains unknown whether patients with PD can gain control of the pathological oscillations recorded from a subcortical site - the STN - with neurofeedback training. We tried to address this question in the current study. Specifically, we designed a simple basketball game, in which the position of a basketball changes based on the occurrence of events of temporally increased beta power quantified in real-time. Participants practised in the game to control the position of the basketball, which requires modulation of the beta oscillations recorded from STN local field potentials (LFPs). Our results suggest that it is possible to use neurofeedback training for PD patients to downregulate pathological beta oscillations in STN LFPs, and that this can lead to a reduction of beta oscillations in the cortical-STN motor network. |
| spellingShingle | He, S Syed, E Torrecillos, F Tinkhauser, G Fischer, P Pogosyan, A Pereira, E Ashkan, K Hasegawa, H Brown, P Tan, H Beta oscillation-targeted neurofeedback training based on subthalamic LFPs in Parkinsonian patients |
| title | Beta oscillation-targeted neurofeedback training based on subthalamic LFPs in Parkinsonian patients |
| title_full | Beta oscillation-targeted neurofeedback training based on subthalamic LFPs in Parkinsonian patients |
| title_fullStr | Beta oscillation-targeted neurofeedback training based on subthalamic LFPs in Parkinsonian patients |
| title_full_unstemmed | Beta oscillation-targeted neurofeedback training based on subthalamic LFPs in Parkinsonian patients |
| title_short | Beta oscillation-targeted neurofeedback training based on subthalamic LFPs in Parkinsonian patients |
| title_sort | beta oscillation targeted neurofeedback training based on subthalamic lfps in parkinsonian patients |
| work_keys_str_mv | AT hes betaoscillationtargetedneurofeedbacktrainingbasedonsubthalamiclfpsinparkinsonianpatients AT syede betaoscillationtargetedneurofeedbacktrainingbasedonsubthalamiclfpsinparkinsonianpatients AT torrecillosf betaoscillationtargetedneurofeedbacktrainingbasedonsubthalamiclfpsinparkinsonianpatients AT tinkhauserg betaoscillationtargetedneurofeedbacktrainingbasedonsubthalamiclfpsinparkinsonianpatients AT fischerp betaoscillationtargetedneurofeedbacktrainingbasedonsubthalamiclfpsinparkinsonianpatients AT pogosyana betaoscillationtargetedneurofeedbacktrainingbasedonsubthalamiclfpsinparkinsonianpatients AT pereirae betaoscillationtargetedneurofeedbacktrainingbasedonsubthalamiclfpsinparkinsonianpatients AT ashkank betaoscillationtargetedneurofeedbacktrainingbasedonsubthalamiclfpsinparkinsonianpatients AT hasegawah betaoscillationtargetedneurofeedbacktrainingbasedonsubthalamiclfpsinparkinsonianpatients AT brownp betaoscillationtargetedneurofeedbacktrainingbasedonsubthalamiclfpsinparkinsonianpatients AT tanh betaoscillationtargetedneurofeedbacktrainingbasedonsubthalamiclfpsinparkinsonianpatients |