Flexible strategy for the synthesis of pyrrolizidine alkaloids.

Flexible strategy for the synthesis of pyrrolizidine alkaloids.

A general strategy for the production of pyrrolizidine alkaloids is described, starting from intermediate (+)-9. The key features are diastereoselective dihydroxylation, inversion at the ring junction by hydroboration of an enamine, and ring closure to form the bicyclo ring system. This route is att...

সম্পূর্ণ বিবরণ

গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Donohoe, T, Thomas, R, Cheeseman, MD, Rigby, C, Bhalay, G, Linney, I
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: 2008
বিবরন
সংক্ষিপ্ত:A general strategy for the production of pyrrolizidine alkaloids is described, starting from intermediate (+)-9. The key features are diastereoselective dihydroxylation, inversion at the ring junction by hydroboration of an enamine, and ring closure to form the bicyclo ring system. This route is attractive because of its brevity and versatility; four natural products were prepared with differing stereochemistry and substitution patterns. Finally, this work allowed assignment of the absolute stereochemistry of 2,3,7-triepiaustraline and hyacinthacine A 7.

অনুরূপ উপাদানগুলি