Diversely substituted quinolines via rhodium-catalyzed alkyne hydroacylation
The Rh-catalyzed hydroacylative union of aldehydes and o-alkynyl anilines leads to 2-aminophenyl enones, and onwards to substituted quinolines. The mild reaction conditions employed in this chemistry result in a process that displays broad functional group tolerance allowing the preparation of div...
| Main Authors: | , , , |
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| Format: | Journal article |
| Published: |
American Chemical Society
2016
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| Summary: | The Rh-catalyzed hydroacylative union of aldehydes and o-alkynyl anilines leads to 2-aminophenyl enones, and onwards to substituted quinolines. The mild reaction conditions employed in this chemistry result in a process that displays broad functional group tolerance allowing the preparation of diversely substituted quinolines in high yields. Extension to the use of o-alkynyl nitro arenes as substrates, leads to 2-nitrochalcones, from which both quinolines and quinoline N-oxides can be accessed.> |
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